Rosyidi Rohadi Muhammad, Wardhana Dewa Putu Wisnu, Priyanto Bambang, Januarman Januarman, Zulkarnaen Decky Aditya, Prihatina Lale Maulin, Rusidi Hanan Anwar, Rozikin Rozikin
Department of Neurosurgery, Medical Faculty, Mataram University, General Province West Nusa Tenggara Hospitals, Mataram, Indonesia.
Department of Neurosurgery, Udayana University Hospital, Medical Faculty of Udayana University, Bali, Indonesia.
Surg Neurol Int. 2024 Jun 28;15:217. doi: 10.25259/SNI_170_2024. eCollection 2024.
Traumatic brain injury (TBI) is a global health problem with the potential to cause dangerous neurological problems. Based on histopathological findings in Sprague Dawley (SD) rats with TBI in the acute phase, the study seeks to discover the effect of , cinnamon, and spirulina as neuroprotective.
We conducted an experimental study with 30 SD rats randomly divided into three groups. The intervention was the administration of , cinnamon, and spirulina to the control and the experimental groups. Histological features were assessed using hematoxylin and eosin (H&E) staining and immunohistochemical examination. The data were analyzed using statistical analysis through correlation tests.
The test samples' average body weights had > 0.05, indicating no significant difference in the test sample body weights. Therefore, the variations in the expression level of the dependent variable were expected to be caused by the induction of brain injury and the administration of , cinnamon, and spirulina. In addition, the variables were not normally distributed. Thus, the Spearman test was carried out and showed the correlation was very strong, with a value of r = 0.818 and < 0.05.
Based on histopathological findings from the brains of SD rats with TBI, pegagan, cinnamon, and spirulina will protect the brain (neuroprotective) in the acute phase.
创伤性脑损伤（TBI）是一个全球性的健康问题，有可能导致危险的神经问题。基于急性创伤性脑损伤的斯普拉格-道利（SD）大鼠的组织病理学发现，本研究旨在探索积雪草、肉桂和螺旋藻的神经保护作用。
我们进行了一项实验研究，将30只SD大鼠随机分为三组。干预措施是对对照组和实验组给予积雪草、肉桂和螺旋藻。使用苏木精和伊红（H&E）染色及免疫组织化学检查评估组织学特征。通过相关性检验使用统计分析对数据进行分析。
测试样本的平均体重具有>0.05，表明测试样本体重无显著差异。因此，预计因变量表达水平的变化是由脑损伤诱导以及给予积雪草、肉桂和螺旋藻所致。此外，变量并非正态分布。因此，进行了斯皮尔曼检验，结果显示相关性非常强，r值 = 0.818且<0.05。
基于创伤性脑损伤的SD大鼠大脑的组织病理学发现，积雪草、肉桂和螺旋藻在急性期可保护大脑（具有神经保护作用）。
