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积雪草苷的神经保护机制。

Neuroprotective mechanisms of Asiatic acid.

作者信息

Ding Liuyun, Liu Tiantian, Ma Jin

机构信息

Department of Emergency Medicine, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China.

Shanghai Seventh's People's Hospital, An Affiliate of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China.

出版信息

Heliyon. 2023 Apr 26;9(5):e15853. doi: 10.1016/j.heliyon.2023.e15853. eCollection 2023 May.

Abstract

Asiatic acid (AA) is the most crucial component of Asiaticoside in many edible and medicinal plants. It has diverse biological activities such as anti-inflammatory, antioxidant, anti-infective, and anti-tumor. Additionally, AA has been intensively studied in the last decades. It has shown great potential in the treatment of various neurological diseases such as spinal cord injury (SCI), cerebral ischemia, epilepsy, traumatic brain injury (TBI), neural tumors, Alzheimer's disease (AD), and Parkinson's disease (PD). Moreover, AA provides pertinent data for neuroprotective signaling pathways, and its substantial neuroprotective ability makes it a novel candidate for developing drugs that target the central nervous system.

摘要

积雪草苷酸(AA)是许多食用和药用植物中积雪草苷的最关键成分。它具有多种生物活性,如抗炎、抗氧化、抗感染和抗肿瘤。此外,在过去几十年中,AA受到了深入研究。它在治疗各种神经系统疾病方面显示出巨大潜力,如脊髓损伤(SCI)、脑缺血、癫痫、创伤性脑损伤(TBI)、神经肿瘤、阿尔茨海默病(AD)和帕金森病(PD)。此外,AA为神经保护信号通路提供了相关数据,其强大的神经保护能力使其成为开发针对中枢神经系统药物的新型候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe82/10172897/a497f5756c8f/gr1.jpg

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