Mr Zaripova, Sn Gayibova, Rr Makhmudov, Aa Mamadrahimov, Nl Vypova, Ug Gayibov, Sm Miralimova, Tf Aripov
Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent 100125, Uzbekistan.
Institute of Microbiology, Academy of Science of Uzbekistan, Tashkent 100128, Uzbekistan.
Prev Nutr Food Sci. 2024 Jun 30;29(2):135-145. doi: 10.3746/pnf.2024.29.2.135.
Plant extracts have been widely used in traditional medicine to prevent diabetes. The present study aimed to examine the antihyperglycemic properties of an ethanolic extract from roots. evaluation revealed that treatment with the extract resulted in significant reactive oxygen species inhibition, glucose binding, glucose transporter activation, and suppression of α-amylase and α-glucosidase. Moreover, the treatment with 100 mg/kg of extract dramatically decreased glucose levels in glucose-, alloxan-, or adrenaline-induced diabetic rats. The information gathered in this study bridges the knowledge gap between traditional healers in Uzbekistan who utilize and its potential for future medication development.
植物提取物在传统医学中已被广泛用于预防糖尿病。本研究旨在检测一种来自根部的乙醇提取物的降血糖特性。评估显示,用该提取物处理可显著抑制活性氧、葡萄糖结合、激活葡萄糖转运蛋白以及抑制α-淀粉酶和α-葡萄糖苷酶。此外,用100mg/kg的提取物处理可显著降低葡萄糖、四氧嘧啶或肾上腺素诱导的糖尿病大鼠的血糖水平。本研究收集的信息填补了乌兹别克斯坦使用[提取物名称未给出]的传统治疗师与未来药物开发潜力之间的知识空白。