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景天科植物的特性：植物成分、抗氧化及降血糖活性

Characterization of (Crassulaceae): Phytocomposition, Antioxidant and Antihyperglycemic Activities.

作者信息

Mr Zaripova, Sn Gayibova, Rr Makhmudov, Aa Mamadrahimov, Nl Vypova, Ug Gayibov, Sm Miralimova, Tf Aripov

机构信息

Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent 100125, Uzbekistan.

Institute of Microbiology, Academy of Science of Uzbekistan, Tashkent 100128, Uzbekistan.

出版信息

Prev Nutr Food Sci. 2024 Jun 30;29(2):135-145. doi: 10.3746/pnf.2024.29.2.135.

DOI:10.3746/pnf.2024.29.2.135
PMID:38974598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11223926/
Abstract

Plant extracts have been widely used in traditional medicine to prevent diabetes. The present study aimed to examine the antihyperglycemic properties of an ethanolic extract from roots. evaluation revealed that treatment with the extract resulted in significant reactive oxygen species inhibition, glucose binding, glucose transporter activation, and suppression of α-amylase and α-glucosidase. Moreover, the treatment with 100 mg/kg of extract dramatically decreased glucose levels in glucose-, alloxan-, or adrenaline-induced diabetic rats. The information gathered in this study bridges the knowledge gap between traditional healers in Uzbekistan who utilize and its potential for future medication development.

摘要

植物提取物在传统医学中已被广泛用于预防糖尿病。本研究旨在检测一种来自根部的乙醇提取物的降血糖特性。评估显示，用该提取物处理可显著抑制活性氧、葡萄糖结合、激活葡萄糖转运蛋白以及抑制α-淀粉酶和α-葡萄糖苷酶。此外，用100mg/kg的提取物处理可显著降低葡萄糖、四氧嘧啶或肾上腺素诱导的糖尿病大鼠的血糖水平。本研究收集的信息填补了乌兹别克斯坦使用[提取物名称未给出]的传统治疗师与未来药物开发潜力之间的知识空白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/133d/11223926/72cfe12e2b91/pnfs-29-2-135-f7.jpg
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Life (Basel). 2022 Oct 25;12(11):1692. doi: 10.3390/life12111692.
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Cureus. 2022 Sep 13;14(9):e29142. doi: 10.7759/cureus.29142. eCollection 2022 Sep.
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Antihyperglycemic and hypoglycemic activities of the aqueous leaf extract of (Rosacea) in mice.（酒渣鼻）叶水提取物对小鼠的降血糖和低血糖活性。 （注：原文中“(Rosacea)”指代不明，可能存在信息缺失）
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Simultaneous Determination of 78 Compounds of Extract by Supercritical CO-Extraction and HPLC-ESI-MS/MS Spectrometry.超临界CO₂萃取结合HPLC-ESI-MS/MS法同时测定提取物中的78种化合物
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