Hoogendijk J E, Fliers E, Swaab D F, Verwer R W
J Neurol Sci. 1985 Jul;69(3):291-9. doi: 10.1016/0022-510x(85)90141-8.
A recent study has shown that vasopressin (AVP) cells in the human supraoptic (SON) and paraventricular (PVN) nuclei increase in size after 60 years of age, suggesting that AVP production is increased in senescence. In the present study, the same brain material was used for the determination of nucleolar size in immunocytochemically identified AVP and oxytocin (OXT) neurons as an additional parameter for peptide production. A strong correlation was found between nucleolar size and cell size, both in AVP and OXT neurons. Nucleolar size of AVP but not of OXT neurons increased significantly in senescence. Observations in brains from patients with senile dementia of the Alzheimer type (SDAT) were commensurate with their ages. These results strongly support the hypothesis that AVP neurons in the SON and PVN are activated in old age.
最近的一项研究表明，60岁以后，人类视上核（SON）和室旁核（PVN）中的加压素（AVP）细胞体积增大，这表明衰老过程中AVP的分泌增加。在本研究中，使用相同的脑材料来测定免疫细胞化学鉴定的AVP和催产素（OXT）神经元的核仁大小，作为肽分泌的另一个参数。在AVP和OXT神经元中，均发现核仁大小与细胞大小之间存在强相关性。衰老过程中，AVP神经元的核仁大小显著增加，而OXT神经元的核仁大小则无显著变化。阿尔茨海默型老年痴呆症（SDAT）患者大脑的观察结果与他们的年龄相符。这些结果有力地支持了以下假设：SON和PVN中的AVP神经元在老年时被激活。
