Chumroenvidhayakul Siriwan, Thilavech Thavaree, Abeywardena Mahinda Yapa, Conlon Michael, Dallimore Julie, Adams Michael, Muhlhausler Beverly, Adisakwattana Sirichai
Center of Excellence in Phytochemical and Functional Food for Clinical Nutrition, Department of Nutrition and Dietetics, Faculty of Allied Health Science, Chulalongkorn University, Bangkok 10330, Thailand.
School of Food Industry, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.
Antioxidants (Basel). 2025 Mar 6;14(3):319. doi: 10.3390/antiox14030319.
Metabolic dysfunction and hepatic abnormalities, such as those associated with high-fat, high-fructose (HFHFr) diets, are major contributors to obesity-related health issues. The growing interest in sustainable dietary interventions has highlighted the potential of plant-based byproducts. Dragon fruit () peel waste, rich in bioactive compounds such as dietary fibers, phenolics, and betacyanins, represents a promising functional ingredient for managing these disorders. This study investigated the effects of dragon fruit peel powder (DFP) on metabolic dysfunction and hepatic abnormalities induced by a HFHFr diet in rats. Over 12 weeks, the rats were fed a standard AIN-93M diet (control or C), C with 5% (/) DFP (C + DFP), a HFHFr diet, or a HFHFr diet with 5% (/) DFP (HFHFr + DFP). DFP supplementation significantly reduced HFHFr-induced body weight gain, visceral adiposity, insulin resistance, and dyslipidemia while also lowering systolic blood pressure and systemic oxidative stress markers. In the liver, DFP supplementation attenuated fat accumulation and lipid peroxidation, reduced glycogen storage abnormalities, and modulated the expression of lipid metabolism and inflammatory genes. These findings suggest that DFP may serve as a functional dietary supplement for preventing and managing metabolic disorders and liver abnormalities associated with excessive fat and fructose consumption.
代谢功能障碍和肝脏异常，例如与高脂、高果糖（HFHFr）饮食相关的情况，是肥胖相关健康问题的主要促成因素。对可持续饮食干预措施的兴趣日益浓厚，这凸显了植物性副产品的潜力。火龙果果皮废料富含膳食纤维、酚类化合物和甜菜色素等生物活性化合物，是管理这些疾病的一种有前景的功能性成分。本研究调查了火龙果果皮粉（DFP）对HFHFr饮食诱导的大鼠代谢功能障碍和肝脏异常的影响。在12周的时间里，给大鼠喂食标准AIN - 93M饮食（对照组或C组）、含5%（/）DFP的C组饮食（C + DFP组）、HFHFr饮食或含5%（/）DFP的HFHFr饮食（HFHFr + DFP组）。补充DFP显著降低了HFHFr诱导的体重增加、内脏脂肪过多、胰岛素抵抗和血脂异常，同时还降低了收缩压和全身氧化应激标志物。在肝脏中，补充DFP减轻了脂肪堆积和脂质过氧化，减少了糖原储存异常，并调节了脂质代谢和炎症基因的表达。这些发现表明，DFP可能作为一种功能性膳食补充剂，用于预防和管理与过量脂肪和果糖摄入相关的代谢紊乱和肝脏异常。
