Yan Yufeng, Lu Hongjing, Zheng Yaguo, Lin Song
Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210008, Jiangsu, China.
J Endocr Soc. 2024 Jun 27;8(8):bvae124. doi: 10.1210/jendso/bvae124. eCollection 2024 Jul 1.
This study aimed to explore the association between the Systemic Immune-Inflammation Index (SII) and diabetes mellitus (DM) and to assess its influence on the prognosis of the DM and no-DM groups.
The study used data from the National Health and Nutrition Examination Survey; 9643 participants were included. Logistic regression analysis was employed to evaluate connections between SII and DM. We used the Cox proportional hazards model, restricted cubic spline, and Kaplan-Meier curve to analyze the relationship between SII and mortality.
The logistic regression analysis indicated that a significant increase in the likelihood of developing DM with higher SII levels (odds ratio, 1.31; 95% CI, 1.09-1.57, = .003). The Cox model showed that there is a positive association between increased SII and higher all-cause mortality. The hazard ratios for SII were 1.53 (1.31, 1.78), 1.61 (1.31, 1.98), and 1.41 (1.12, 1.78) in the total, DM and non-DM groups, respectively. We observed a linear correlation between SII and all-cause mortality in DM participants, whereas non-DM participants and the total population showed a nonlinear correlation.
Elevated SII levels are linked to an augmented risk of DM. Those with DM and higher SII levels demonstrated an elevated risk of mortality.
本研究旨在探讨全身免疫炎症指数（SII）与糖尿病（DM）之间的关联，并评估其对DM组和非DM组预后的影响。
本研究使用了来自美国国家健康与营养检查调查的数据；纳入了9643名参与者。采用逻辑回归分析来评估SII与DM之间的联系。我们使用Cox比例风险模型、受限立方样条和Kaplan-Meier曲线来分析SII与死亡率之间的关系。
逻辑回归分析表明，随着SII水平升高，患DM的可能性显著增加（优势比，1.31；95%CI，1.09-1.57，P = .003）。Cox模型显示，SII升高与全因死亡率升高呈正相关。在总人群、DM组和非DM组中，SII的风险比分别为1.53（1.31，1.78）、1.61（1.31，1.98）和1.41（1.12，1.78）。我们观察到DM参与者中SII与全因死亡率之间存在线性相关性，而非DM参与者和总人群则表现出非线性相关性。
SII水平升高与DM风险增加有关。DM患者且SII水平较高者的死亡风险升高。
