Yabré Zakaline, Boly Rainatou, Ouédraogo Raogo, Coulidiaty Abdul Gafar Victoir, Somda Gaétan D, Semdé Rasmané, Ouédraogo Noufou, Youl Estelle Noëla Hoho
Drug Development Laboratory (LADME), Center for Training, Research and Expertise in Drug Sciences (CEA-CFOREM), Doctoral School of Health and Sciences (ED2S), Joseph KI-ZERBO University, 03 PO 7021, Ouagadougou, Burkina Faso.
Research Institute for Health Sciences (IRSS), 03 PO 7047, Ouagadougou, Burkina Faso.
Heliyon. 2024 Jun 6;10(12):e32402. doi: 10.1016/j.heliyon.2024.e32402. eCollection 2024 Jun 30.
Linn (Malvaceae) is a widely distributed plant in West Africa. It is commonly used in Burkina Faso to treat inflammation-related diseases, including asthma. Previous reviews have focused on the ethnobotanical, traditional uses, phytochemistry, and pharmacological properties of . This report aims to compile the biological and pharmacological activities that highlight the anti-asthmatic properties of L. ().
Electronic databases, such as PubMed, Scopus, Hinari, SciFinder, Google Scholar, and ScienceDirect, were used to gather data on . Data on the toxicological, anti-inflammatory, antioxidant, and bronchorelaxant effects of were collected.
Twenty-three studies describing the biological and pharmacological activities relevant to assessing the anti-asthmatic properties of were found. Nine articles investigated the anti-inflammatory effects, and three manuscripts were found to have bronchorelaxant activity. Five publications reported the antioxidant activity of the plant extracts. Research on the extracts revealed a tolerable safety profile in rats and mice with an LD ranging from 300 to 5000 mg/kg body weight, depending on the parts of the plant used. Phenolic compounds, particularly flavonoids, alkaloids, and saponins, were found to be responsible for the activities involved in the assessment of anti-asthmatic properties.
The results of this review suggest that could be a valuable resource for the treatment of asthma and other respiratory diseases. However, further chemical and pharmacological investigations are needed to understand its mechanism of action in treating asthma.
亚麻（锦葵科）是一种在西非广泛分布的植物。在布基纳法索，它常用于治疗包括哮喘在内的炎症相关疾病。以往的综述主要关注其民族植物学、传统用途、植物化学和药理学特性。本报告旨在汇总突出亚麻抗哮喘特性的生物学和药理学活性。
使用电子数据库，如PubMed、Scopus、Hinari、SciFinder、谷歌学术和ScienceDirect，收集有关亚麻的数据。收集了亚麻的毒理学、抗炎、抗氧化和支气管舒张作用的数据。
发现了23项描述与评估亚麻抗哮喘特性相关的生物学和药理学活性的研究。9篇文章研究了其抗炎作用，3篇手稿发现具有支气管舒张活性。5篇出版物报道了植物提取物的抗氧化活性。对提取物的研究表明，在大鼠和小鼠中具有可耐受的安全性，根据所使用植物部位的不同，半数致死量范围为300至5000毫克/千克体重。发现酚类化合物，特别是黄酮类、生物碱和皂苷，是参与评估抗哮喘特性的活性成分。
本综述结果表明，亚麻可能是治疗哮喘和其他呼吸系统疾病的宝贵资源。然而，需要进一步的化学和药理学研究来了解其治疗哮喘的作用机制。
