A review of the safety profile, antioxidant, anti-inflammatory, and bronchorelaxant activities of Linn (Malvaceae): A potential antiasthmatic phytomedicine.

INTRODUCTION

Linn (Malvaceae) is a widely distributed plant in West Africa. It is commonly used in Burkina Faso to treat inflammation-related diseases, including asthma. Previous reviews have focused on the ethnobotanical, traditional uses, phytochemistry, and pharmacological properties of . This report aims to compile the biological and pharmacological activities that highlight the anti-asthmatic properties of L. ().

METHOD

Electronic databases, such as PubMed, Scopus, Hinari, SciFinder, Google Scholar, and ScienceDirect, were used to gather data on . Data on the toxicological, anti-inflammatory, antioxidant, and bronchorelaxant effects of were collected.

RESULTS

Twenty-three studies describing the biological and pharmacological activities relevant to assessing the anti-asthmatic properties of were found. Nine articles investigated the anti-inflammatory effects, and three manuscripts were found to have bronchorelaxant activity. Five publications reported the antioxidant activity of the plant extracts. Research on the extracts revealed a tolerable safety profile in rats and mice with an LD ranging from 300 to 5000 mg/kg body weight, depending on the parts of the plant used. Phenolic compounds, particularly flavonoids, alkaloids, and saponins, were found to be responsible for the activities involved in the assessment of anti-asthmatic properties.

CONCLUSION

The results of this review suggest that could be a valuable resource for the treatment of asthma and other respiratory diseases. However, further chemical and pharmacological investigations are needed to understand its mechanism of action in treating asthma.