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无活动性或慢性丙型肝炎感染情况下导致终末期肾病的纤维性肾小球肾炎：当前见解

Fibrillary Glomerulonephritis Leading to End-Stage Renal Disease in the Absence of Active or Chronic Hepatitis C Infection: Current Insights.

作者信息

Saleem Maryam, Khan Maahin M, Iftikhar Hassaan

机构信息

Nephrology, Ohio Valley Nephrology Associates, Owensboro, USA.

Nephrology, Washington University School of Medicine in St. Louis, St. Louis, USA.

出版信息

Cureus. 2024 Jun 6;16(6):e61831. doi: 10.7759/cureus.61831. eCollection 2024 Jun.

DOI:10.7759/cureus.61831
PMID:38975465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11227315/
Abstract

Fibrillary glomerulonephritis (FGN) is a rare glomerular disease with various etiologies, including idiopathic cases and associations with autoimmune diseases, neoplasms, and viral infections, such as Hepatitis C. We present a case of a patient who developed acute kidney injury (AKI) with atypical clinical features. A subsequent renal biopsy confirmed the diagnosis of FGN, with distinct immunofluorescence staining for DNAJB9. The patient tested positive for Hepatitis C antibodies with an undetectable viral load, indicating a past infection that had self-cleared. This finding prompted further investigation of the association between Hepatitis C and the development of FGN.

摘要

纤维性肾小球肾炎（FGN）是一种病因多样的罕见肾小球疾病，包括特发性病例以及与自身免疫性疾病、肿瘤和病毒感染（如丙型肝炎）相关的病例。我们报告一例具有非典型临床特征的急性肾损伤（AKI）患者。随后的肾活检确诊为FGN，DNAJB9免疫荧光染色明显。该患者丙型肝炎抗体检测呈阳性，但病毒载量检测不到，表明既往感染已自行清除。这一发现促使进一步研究丙型肝炎与FGN发生之间的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11227315/beae2e59c867/cureus-0016-00000061831-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11227315/7d29bc0402be/cureus-0016-00000061831-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11227315/1764809e8b27/cureus-0016-00000061831-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11227315/1392d45065df/cureus-0016-00000061831-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11227315/beae2e59c867/cureus-0016-00000061831-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11227315/7d29bc0402be/cureus-0016-00000061831-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11227315/1764809e8b27/cureus-0016-00000061831-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11227315/1392d45065df/cureus-0016-00000061831-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11227315/beae2e59c867/cureus-0016-00000061831-i04.jpg

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本文引用的文献

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Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response.纤维性肾小球肾炎、DNAJB9与未折叠蛋白反应
Glomerular Dis. 2022 Jun 16;2(4):164-175. doi: 10.1159/000525542. eCollection 2022.
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Subclass Changes in Fibrillary Glomerulonephritis.纤维性肾小球肾炎的亚类变化
Kidney Int Rep. 2022 Sep 29;8(1):202-205. doi: 10.1016/j.ekir.2022.09.020. eCollection 2023 Jan.
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Fibrillary Glomerulonephritis and DnaJ Homolog Subfamily B Member 9 (DNAJB9).纤维状肾小球肾炎和 DNAJ 同源物亚家族 B 成员 9（DNAJB9）。
Kidney360. 2020 Jul 8;1(9):1002-1013. doi: 10.34067/KID.0002532020. eCollection 2020 Sep 24.
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Clin J Am Soc Nephrol. 2019 Dec 6;14(12):1741-1750. doi: 10.2215/CJN.03870319. Epub 2019 Nov 4.
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Fibrillary Glomerulonephritis: An Update.纤维性肾小球肾炎：最新进展
Kidney Int Rep. 2019 Apr 29;4(7):917-922. doi: 10.1016/j.ekir.2019.04.013. eCollection 2019 Jul.
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New developments in the diagnosis of fibrillary glomerulonephritis.纤维状肾小球肾炎的诊断新进展。
Kidney Int. 2019 Sep;96(3):581-592. doi: 10.1016/j.kint.2019.03.021. Epub 2019 Apr 9.
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HCV-Associated Nephropathies in the Era of Direct Acting Antiviral Agents.直接抗病毒药物时代的丙型肝炎病毒相关肾病
Front Med (Lausanne). 2019 Feb 8;6:20. doi: 10.3389/fmed.2019.00020. eCollection 2019.
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Fibrillary glomerulonephritis: a report of 66 cases from a single institution.纤维状肾小球肾炎：单中心 66 例报告。
Clin J Am Soc Nephrol. 2011 Apr;6(4):775-84. doi: 10.2215/CJN.08300910. Epub 2011 Mar 24.
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Rituximab treatment of dysproteinemias affecting the kidney: a review of three cases.利妥昔单抗治疗影响肾脏的异常蛋白血症：三例病例回顾
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Fibrillary and immunotactoid glomerulonephritis: Distinct entities with different clinical and pathologic features.纤维样和免疫触须样肾小球肾炎：具有不同临床和病理特征的不同实体。
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