Gryglewski R J, Korbut R, Splawinski J
Haemostasis. 1979;8(3-5):294-9. doi: 10.1159/000214319.
When infused intravenously into anaesthetized cats angiotensin II (1--4 micrograms/kg) released into the circulation an unstable substance that caused de-aggregation of platelet clumps, relaxed a strip of bovine coronary artery, and its release was blocked by aspirin and indomethacin. Because of these characteristics this substance is likely to be prostacyclin. Catecholamines and phenylephrine did not induce the release of prostacyclin. It is suggested that a chemical modification of the molecule of angiotensin II may render a peptide with little hypertensive properties which will be an activator of prostacyclin biosynthesis.
当将血管紧张素II（1 - 4微克/千克）静脉注入麻醉猫体内时，它会在循环中释放出一种不稳定物质，该物质可导致血小板聚集体解聚，使一条牛冠状动脉条带松弛，且其释放受到阿司匹林和吲哚美辛的阻断。由于这些特性，这种物质可能是前列环素。儿茶酚胺和去氧肾上腺素不会诱导前列环素的释放。有人提出，对血管紧张素II分子进行化学修饰可能会产生一种几乎没有高血压特性的肽，它将是前列环素生物合成的激活剂。
