Mullane K M, Moncada S
Prostaglandins. 1980 Jul;20(1):25-49. doi: 10.1016/0090-6980(80)90004-0.
Prostaglandin release into the circulation of the dog was studied by means of the blood-bathed bioassay system of Vane. Bradykinin, angiotensin II and angiotensin I selectively released a prostacyclin-like substance into the circulation, whereas no release was detected with adrenaline, noradrenaline, 5-hydroxytryptamine or acetylcholine. Release induced by bradykinin was mainly of renal origin, whereas that induced by the angiotensins was of more widespread origin, including the lungs and kidneys. No thromboxane A2 or prostaglandin-like substance could be detected from blood by any of these stimuli. Prostacyclin released by bradykinin contributed to the vascular actions of the kinin as indicated by treatment with cyclo-oxygenase inhibitors. Prostacyclin release also contributed to a reduced pressor effect of angiotensin II. This study indicates that prostacyclin release induced by the vasoactive peptides modulates some of their vascular actions.
利用范恩的血浴生物测定系统研究了前列腺素释放到犬循环系统中的情况。缓激肽、血管紧张素II和血管紧张素I选择性地将一种前列环素样物质释放到循环系统中，而肾上腺素、去甲肾上腺素、5-羟色胺或乙酰胆碱未检测到释放。缓激肽诱导的释放主要源于肾脏，而血管紧张素诱导的释放来源更为广泛，包括肺和肾脏。这些刺激均未从血液中检测到血栓素A2或前列腺素样物质。如用环氧化酶抑制剂处理所示，缓激肽释放的前列环素促成了激肽的血管作用。前列环素的释放也促成了血管紧张素II升压作用的减弱。这项研究表明，血管活性肽诱导的前列环素释放调节了它们的一些血管作用。
