首个通过原子经济反应相互作用机制实现的具有多功能的吡咯烷特异性探针。
The first specific probe for pyrrolidine with multifunction by the interaction mechanism of atomic economic reaction.
作者信息
Cao Xi-Ying, Huang Yan, Chen Si-Hong, Yu Shi-Wei, Chen Zu-Jia, Li Zhong-Hao, Zeng Yu, Chen Nan, Cao Liang, Wang Zhao-Yang
机构信息
School of Chemistry, South China Normal University; Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine; GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals; Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou 510006, P.R. China.
The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, P.R. China.
出版信息
iScience. 2024 May 18;27(7):110024. doi: 10.1016/j.isci.2024.110024. eCollection 2024 Jul 19.
Pyrrolidine (PyD) has an important impact on the environment and human health. However, there is currently no method for trace detection of PyD. Here, we successfully designed diaminomethylene-4H-pyran (1) as the first specific fluorescent probe for PyD. Only by adding PyD to probe 1, there is blue fluorescence at 455 nm, and the color of the solution changes from colorless to yellow. The detection limit is 1.12 × 10 M, and the response time is less than 5 min. Meanwhile, probe 1 can also sense the gaseous PyD and detect PyD in actual water samples. Moreover, due to the low biological toxicity, probe 1 can detect the exogenous PyD in zebrafish. The preliminary mechanism shows that probe 1 and PyD undergo a combination-type chemical reaction to generate a new substance 1-PyD. Therefore, the 100% atom utilization reaction enables probe 1 to exhibit specific adsorption and removal of PyD.
吡咯烷（PyD）对环境和人类健康有重要影响。然而，目前尚无检测PyD痕量的方法。在此，我们成功设计了二氨基亚甲基-4H-吡喃（1）作为首个用于PyD的特异性荧光探针。仅将PyD添加到探针1中，在455 nm处就会出现蓝色荧光，且溶液颜色从无色变为黄色。检测限为1.12×10⁻⁸ M，响应时间小于5分钟。同时，探针1还能检测气态PyD并检测实际水样中的PyD。此外，由于生物毒性低，探针1可检测斑马鱼中的外源PyD。初步机理表明，探针1与PyD发生组合型化学反应生成新物质1-PyD。因此，100%的原子利用率反应使探针1能够特异性吸附和去除PyD。
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