Departamento de Medicina Tropical e Infectologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Departamento de Medicina Tropical e Infectologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Clinics (Sao Paulo). 2024 Jul 8;79:100419. doi: 10.1016/j.clinsp.2024.100419. eCollection 2024.
HIV Pre-Exposure Pophylaxis (PrEP) is provided free of charge by the Brazilian national health system. Though effective in preventing HIV infection, little is known about its impact on the health-related Quality of Life (QoL) of users.
The present study aimed at assessing the impact of PrEP on the QoL of its users.
Prospective cohort study with 114 HIV-negative participants aged 18 years or older. Participants' QoL was assessed before starting PrEP and after 7 months of use, using the self-responsive WHOQOL-bref questionnaire. Sociodemographic and behavioral aspects were described and the Wilcoxon signed-rank test with p ≤ 0.05 was considered statistically significant.
Improvement was seen in QoL scores for the environment domain (p = 0.02), which addresses feeling of physical safety, access to information and health services, and participation in leisure activities. Furthermore, participants reported improved satisfaction with their sex life, when questioned about the social relationships domain. There was no statistically significant change in the global QoL score, in the global health score, in the physical and psychological domains, nor in the total score for the social relationships domain. As for their socio-demographic profile, most participants were white and highly educated young cisgender men who have sex with men. 76.3% had unprotected sex in the 3 months before starting PrEP. 60.5% had reported substance use: marijuana (42.1%), club drugs (35.1%), and poppers (20.2%).
This study unveiled that PrEP benefited our cohort beyond its effectiveness in preventing HIV infection, having improved environmental aspects of QoL and self-satisfaction with sex life.
巴西国家卫生系统免费提供艾滋病毒暴露前预防（PrEP）。尽管 PrEP 能有效预防艾滋病毒感染，但人们对其对使用者健康相关生活质量（QoL）的影响知之甚少。
本研究旨在评估 PrEP 对使用者 QoL 的影响。
这是一项前瞻性队列研究，纳入了 114 名年龄在 18 岁及以上的 HIV 阴性参与者。使用自我报告的世界卫生组织生活质量简表（WHOQOL-bref）问卷，在开始 PrEP 前和使用 7 个月后评估参与者的 QoL。描述了社会人口学和行为方面的情况，Wilcoxon 符号秩检验，p 值≤0.05 被认为具有统计学意义。
环境领域的 QoL 评分有所改善（p = 0.02），该领域涉及身体安全感、获取信息和卫生服务以及参与休闲活动的感受。此外，当被问及社会关系领域时，参与者报告称性生活满意度有所提高。全球 QoL 评分、全球健康评分、生理和心理领域以及社会关系领域的总分均无统计学意义的变化。就他们的社会人口学特征而言，大多数参与者是白人，受过高等教育的年轻顺性别男性同性恋者。76.3%的人在开始 PrEP 前 3 个月有过无保护性行为。60.5%的人报告有物质使用情况：大麻（42.1%）、俱乐部毒品（35.1%）和 poppers（20.2%）。
这项研究表明，PrEP 不仅能有效预防艾滋病毒感染，还能改善环境方面的 QoL 和对性生活的自我满意度，使我们的队列受益。
