• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY).

作者信息

Moore E C, Hurlbert R B

出版信息

Pharmacol Ther. 1985;27(2):167-96. doi: 10.1016/0163-7258(85)90068-3.

DOI:10.1016/0163-7258(85)90068-3
PMID:3898152
Abstract
摘要

相似文献

1
The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY).羟基脲、胍唑和吡唑并咪唑（IMPY）对核糖核苷二磷酸还原酶的抑制作用。
Pharmacol Ther. 1985;27(2):167-96. doi: 10.1016/0163-7258(85)90068-3.
2
Studies on the differential mechanisms of inhibition of ribonucleotide reductase by specific inhibitors of the non-heme iron subunit.非血红素铁亚基特异性抑制剂对核糖核苷酸还原酶抑制作用的差异机制研究
Adv Enzyme Regul. 1984;22:231-41. doi: 10.1016/0065-2571(84)90016-5.
3
Specific inhibition of the subunits of ribonucleotide reductase as a new approach to combination chemotherapy.核糖核苷酸还原酶亚基的特异性抑制作为联合化疗的新方法
Adv Enzyme Regul. 1980;19:139-50. doi: 10.1016/0065-2571(81)90013-3.
4
The utility of combinations of drugs directed at specific sites of the same target enzyme--ribonucleotide reductase as the model.
Adv Enzyme Regul. 1985;23:181-92. doi: 10.1016/0065-2571(85)90047-0.
5
Ribonucleotide reductase from wild type and hydroxyurea-resistant chinese hamster ovary cells.来自野生型和羟基脲抗性中国仓鼠卵巢细胞的核糖核苷酸还原酶。
J Cell Physiol. 1978 Oct;97(1):87-97. doi: 10.1002/jcp.1040970109.
6
DNA repair induced by various mutagens in rat hepatocyte primary cultures measured in the presence of hydroxyurea, guanazole or aphidicolin.在存在羟基脲、胍唑或阿非迪霉素的情况下，测定大鼠原代肝细胞培养物中各种诱变剂诱导的DNA修复。
Mutat Res. 1990 Aug;231(2):251-64. doi: 10.1016/0027-5107(90)90031-x.
7
Mechanisms of drug resistance to inhibitors directed at the individual subunits of ribonucleotide reductase.
Cancer Commun. 1989;1(1):13-20. doi: 10.3727/095535489820875390.
8
A series of N-carbamoyloxyurea resistant cell lines with alterations in ribonucleotide reductase: lack of coordination in pyrimidine and purine reductase activity.
Can J Biochem Cell Biol. 1983 Feb-Mar;61(2-3):120-9. doi: 10.1139/o83-018.
9
Herpes simplex type 1 ribonucleotide reductase. Mechanism studies with inhibitors.单纯疱疹病毒1型核糖核苷酸还原酶。抑制剂的机制研究。
J Biol Chem. 1985 Jul 25;260(15):8694-7.
10
Isolation and initial characterization of a series of Chlamydia trachomatis isolates selected for hydroxyurea resistance by a stepwise procedure.通过逐步程序选择的一系列对羟基脲具有抗性的沙眼衣原体分离株的分离及初步鉴定。
J Bacteriol. 1991 Aug;173(16):4932-40. doi: 10.1128/jb.173.16.4932-4940.1991.

引用本文的文献

1
Replication stalling activates SSB for recruitment of DNA damage tolerance factors.复制停滞会激活单链结合蛋白以招募 DNA 损伤容忍因子。
Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2208875119. doi: 10.1073/pnas.2208875119. Epub 2022 Oct 3.
2
Replication stress induced by the ribonucleotide reductase inhibitor guanazole, triapine and gemcitabine in fission yeast.核酶还原酶抑制剂胍唑、三嗪和吉西他滨在裂殖酵母中引起的复制压力。
FEMS Yeast Res. 2022 Mar 24;22(1). doi: 10.1093/femsyr/foac014.
3
Fragile site instability in Saccharomyces cerevisiae causes loss of heterozygosity by mitotic crossovers and break-induced replication.
酿酒酵母中的脆性位点不稳定性通过有丝分裂交叉和断裂诱导复制导致杂合性丢失。
PLoS Genet. 2013;9(9):e1003817. doi: 10.1371/journal.pgen.1003817. Epub 2013 Sep 19.
4
Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli.羟脲诱导大肠埃希菌产生羟自由基介导的细胞死亡。
Mol Cell. 2009 Dec 11;36(5):845-60. doi: 10.1016/j.molcel.2009.11.024.
5
A reduction in ribonucleotide reductase activity slows down the chromosome replication fork but does not change its localization.核苷酸还原酶活性的降低会减缓染色体复制叉的速度，但不会改变其定位。
PLoS One. 2009 Oct 28;4(10):e7617. doi: 10.1371/journal.pone.0007617.
6
Limited TTP supply affects telomere length regulation in a telomerase-independent fashion.有限的端粒酶逆转录酶（TTP）供应以一种不依赖端粒酶的方式影响端粒长度调节。
Nucleic Acids Res. 2005 Jan 28;33(2):704-13. doi: 10.1093/nar/gki219. Print 2005.
7
Cellular delivery of nucleoside diphosphates: a prodrug approach.核苷二磷酸的细胞递送：一种前药方法。
Pharm Res. 1997 Jun;14(6):706-12. doi: 10.1023/a:1012133902314.
8
Biochemical and antitumor activity of trimidox, a new inhibitor of ribonucleotide reductase.新型核糖核苷酸还原酶抑制剂三甲氧苄二氨嘧啶的生化及抗肿瘤活性
Cancer Chemother Pharmacol. 1994;34(1):63-6. doi: 10.1007/BF00686113.
9
Deoxyadenosine reverses hydroxyurea inhibition of vaccinia virus growth.脱氧腺苷可逆转羟基脲对痘苗病毒生长的抑制作用。
J Virol. 1991 May;65(5):2290-8. doi: 10.1128/JVI.65.5.2290-2298.1991.
10
Reduction of ribonucleotides by the obligate intracytoplasmic bacterium Rickettsia prowazekii.专性胞内细菌普氏立克次氏体对核糖核苷酸的还原作用。
J Bacteriol. 1991 Feb;173(4):1471-7. doi: 10.1128/jb.173.4.1471-1477.1991.