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儿童复方磺胺甲恶唑的临床研究。

Clinical studies on co-trimazine in children.

作者信息

Bergfors P G

出版信息

Infection. 1979;7 Suppl 4:S408-10. doi: 10.1007/BF01639023.

DOI:10.1007/BF01639023
PMID:389816
Abstract

A study of co-trimazine tablets in 52 cases of urinary tract infection in children has shown that co-trimazine is at least as effective as co-trimoxazole, in which both the sulphonamide and the trimethoprim dose is higher than with co-trimazine. The frequency of side-effects (gastro-intestinal intolerance and allergic manifestations) was low. A sucrose-free suspension of cotrimazine for use in younger children was tested and found to have very good properties, as judged by a high acceptability rate among the young patients. Only one of 44 children refused to take the medicine during the prescribed fourteen days of therapy.

摘要

一项针对52例儿童尿路感染患者使用复方磺胺嘧啶片的研究表明,复方磺胺嘧啶至少与复方新诺明一样有效,复方新诺明中磺胺类药物和甲氧苄啶的剂量均高于复方磺胺嘧啶。副作用(胃肠道不耐受和过敏表现)的发生率较低。对用于年幼儿童的无糖复方磺胺嘧啶混悬液进行了测试,从年轻患者的高接受率判断,发现其具有非常好的特性。在规定的14天治疗期间,44名儿童中只有1名拒绝服药。

相似文献

1
Clinical studies on co-trimazine in children.儿童复方磺胺甲恶唑的临床研究。
Infection. 1979;7 Suppl 4:S408-10. doi: 10.1007/BF01639023.
2
A clinical study of co-trimazine in comparison with co-trimoxazole and sulphalene in urinary tract infections.复方磺胺嘧啶与复方新诺明和磺胺林治疗尿路感染的临床研究。
Infection. 1979;7 Suppl 4:S401-3. doi: 10.1007/BF01639021.
3
Clinical study of co-trimazine in urinary tract infections: a comparison with nitrofurantoin.复方磺胺甲恶唑治疗尿路感染的临床研究:与呋喃妥因的比较。
Infection. 1979;7 Suppl 4:S411-3. doi: 10.1007/BF01639024.
4
Comparative trial of sulphadiazine-trimethoprim (co-trimazine), co-trimoxazole and sulphamethizole in the treatment of uncomplicated urinary tract infections.磺胺嘧啶-甲氧苄啶(复方磺胺嘧啶)、复方新诺明与磺胺甲噻二唑治疗单纯性尿路感染的对比试验
N Z Med J. 1980 Jan 23;91(652):43-4.
5
The use of co-trimazine and co-trimoxazole in elderly patients with urinary tract infections.复方磺胺嘧啶和复方新诺明在老年尿路感染患者中的应用。
Infection. 1979;7 Suppl 4:S404-7. doi: 10.1007/BF01639022.
6
Three-day treatment of acute lower urinary tract infections in women. A double-blind study with amoxycillin and co-trimazine.女性急性下尿路感染的三日疗法。阿莫西林与复方新诺明的双盲研究。
Acta Med Scand. 1983;213(1):55-60. doi: 10.1111/j.0954-6820.1983.tb03690.x.
7
Clinical pharmacokinetics of co-trimazine.复方磺胺甲恶唑的临床药代动力学。
Clin Pharmacokinet. 1986 Sep-Oct;11(5):372-86. doi: 10.2165/00003088-198611050-00003.
8
Treatment of urinary tract infections in general practice with sulfamethizole, trimethoprim or co-trimazine (sulphadiazine-trimethoprim).在普通医疗实践中使用磺胺甲噻二唑、甲氧苄啶或复方新诺明(磺胺嘧啶 - 甲氧苄啶)治疗尿路感染。
J Antimicrob Chemother. 1980 Nov;6(6):701-8. doi: 10.1093/jac/6.6.701.
9
Trimethoprim-sulphadiazine prophylaxis in children with vesico-ureteric reflux.甲氧苄啶-磺胺嘧啶对膀胱输尿管反流患儿的预防作用
Scand J Infect Dis. 1989;21(2):201-4. doi: 10.3109/00365548909039969.
10
Development of sulphonamide-trimethoprim combinations for urinary tract infections. Part 3: Pharmacokinetic characterization of sulphadiazine and sulphamethoxazole given with trimethoprim.用于尿路感染的磺胺类药物-甲氧苄啶联合制剂的研发。第3部分:磺胺嘧啶和磺胺甲恶唑与甲氧苄啶联用的药代动力学特征。
Infection. 1979;7 Suppl 4:S371-81. doi: 10.1007/BF01639016.

引用本文的文献

1
Trimethoprim/sulphonamide: concluding remarks.甲氧苄啶/磺胺类药物:总结发言。
Infection. 1979;7 Suppl 4:S417-8. doi: 10.1007/BF01639026.

本文引用的文献

1
Effects of mouth rinses with sucrose, glucose, fructose, lactose, sorbitol and Lycasin on the pH of dental plaque.用蔗糖、葡萄糖、果糖、乳糖、山梨醇和氢化淀粉水解物漱口对牙菌斑pH值的影响。
Odontol Revy. 1973;24(3):217-26.
2
Controlled trial of co-trimoxazole in children with urinary-tract infection. Bacteriological efficacy and haematological toxicity.复方新诺明治疗儿童尿路感染的对照试验。细菌学疗效和血液学毒性。
Lancet. 1974 Sep 14;2(7881):614-6. doi: 10.1016/s0140-6736(74)91941-2.