Maykut M O
Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(3):209-38. doi: 10.1016/0278-5846(85)90085-5.
Chemical content, assay procedures, and pharmacokinetics of cannabis sativa are discussed briefly. Cannabinoid cellular effects relating to chromosomes and immunity including cellular metabolism and allergic reactions are presented. Gross and microscopic brain pathology due to cannabis use is reviewed involving EEG alterations, psychopathology including aggressive behaviour as well as properties of psychomotor impairment, tolerance and dependence. Cardiopulmonary effects of marihuana are recorded under pulmonary pharmacological effects including the macrophage defense system and effects of smoke constituents; under cardiovascular effects cardiac toxicity and possible mechanism of action are discussed. Alterations of reproductive hormonal production and maturation of reproductive cells by marihuana in males and females with attendant impairment of reproductive function or fertility including reproductive outcome are reported. Field studies with healthy chronic cannabis users in Jamaica, Greece and Costa Rica are related as to observed medical alterations. Potential clinical effects are summarized in point form.
简要讨论了大麻的化学成分、分析方法和药代动力学。介绍了大麻素与染色体和免疫相关的细胞效应，包括细胞代谢和过敏反应。回顾了因使用大麻导致的大脑大体和微观病理学，涉及脑电图改变、包括攻击行为在内的精神病理学以及精神运动障碍、耐受性和依赖性的特性。记录了大麻对心肺的影响，包括肺部药理作用，如巨噬细胞防御系统和烟雾成分的影响；在心血管作用方面，讨论了心脏毒性和可能的作用机制。报告了大麻对男性和女性生殖激素产生和生殖细胞成熟的影响，以及随之而来的生殖功能或生育能力损害，包括生殖结果。介绍了在牙买加、希腊和哥斯达黎加对健康慢性大麻使用者进行的实地研究中观察到的医学改变。以要点形式总结了潜在的临床效应。
