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整合素在小梁网纤维化发展中的作用。

Role of integrins in the development of fibrosis in the trabecular meshwork.

作者信息

Faralli Jennifer A, Filla Mark S, Peters Donna M

机构信息

Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.

Department of Ophthalmology & Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.

出版信息

Front Ophthalmol (Lausanne). 2023 Oct 24;3:1274797. doi: 10.3389/fopht.2023.1274797. eCollection 2023.

DOI:10.3389/fopht.2023.1274797
PMID:38983065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11182094/
Abstract

Primary open angle glaucoma (POAG) is a progressive and chronic disease exhibiting many of the features of fibrosis. The extracellular matrix (ECM) in the trabecular meshwork (TM) undergoes extensive remodeling and enhanced rigidity, resembling fibrotic changes. In addition, there are changes associated with myofibroblast activation and cell contractility that further drives tissue fibrosis and stiffening. This review discusses what is known about the integrins in the TM and their involvement in fibrotic processes.

摘要

原发性开角型青光眼（POAG）是一种具有许多纤维化特征的进行性慢性疾病。小梁网（TM）中的细胞外基质（ECM）经历广泛重塑并增强硬度，类似于纤维化变化。此外，还存在与肌成纤维细胞活化和细胞收缩性相关的变化，这进一步推动组织纤维化和硬化。本综述讨论了关于小梁网中整合素及其在纤维化过程中的作用的已知信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c21/11182094/6a228c4b2c87/fopht-03-1274797-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c21/11182094/6a594feff0eb/fopht-03-1274797-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c21/11182094/3bbf230da019/fopht-03-1274797-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c21/11182094/2aeb58917334/fopht-03-1274797-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c21/11182094/6a228c4b2c87/fopht-03-1274797-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c21/11182094/6a594feff0eb/fopht-03-1274797-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c21/11182094/3bbf230da019/fopht-03-1274797-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c21/11182094/2aeb58917334/fopht-03-1274797-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c21/11182094/6a228c4b2c87/fopht-03-1274797-g004.jpg

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本文引用的文献

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Cells. 2023 Feb 3;12(3):504. doi: 10.3390/cells12030504.
2
Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma.搏动性小梁网运动：原发性开角型青光眼眼压控制的一个指标
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Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork, retina, and optic nerve damage in mice.
Invest Ophthalmol Vis Sci. 2025 Mar 3;66(3):25. doi: 10.1167/iovs.66.3.25.
4
Integrated Profiling of Extracellular Vesicle microRNA Impact on Trabecular Meshwork mRNA Expression: Insights From Microarray Analysis.细胞外囊泡微小RNA对小梁网mRNA表达影响的综合分析：来自微阵列分析的见解
Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):38. doi: 10.1167/iovs.65.14.38.
纤连蛋白额外结构域A（FN-EDA）可导致小鼠青光眼性小梁网、视网膜和视神经损伤。
Cell Biosci. 2022 May 26;12(1):72. doi: 10.1186/s13578-022-00800-y.
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