Du Rong, Xin Chen, Xu Jingjiang, Hu Jianping, Wang Huaizhou, Wang Ningli, Johnstone Murray
Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China.
J Clin Med. 2022 May 10;11(10):2696. doi: 10.3390/jcm11102696.
(1) Background: To investigate the value of pulsatile trabecular meshwork (TM) motion in predicting the diurnal intraocular pressure (IOP) fluctuation of primary open-angle glaucoma (POAG). (2) Methods: This cross-sectional study recruited 20 normal patients and 30 patients with POAG. Of the POAG group, 20 had stable diurnal IOP and 10 had high IOP fluctuation. A clinical prototype phase-sensitive optical coherence tomography (PhS-OCT) model was used to measure TM pulsatile motion with maximum velocity (MV) and cumulative displacement (CDisp). (3) Results: MV and CDisp were higher in the external region in both normal and POAG patients. All MV and CDisp reduced significantly in the POAG group (p < 0.001). In the POAG group, except MV in the external region (p = 0.085), MV and CDisp in the nasal area were significantly higher than those in the temporal area (p < 0.05). The MV and CDisp in the external region in the nasal area of POAG patients with high IOP fluctuation were much lower than those with stable IOP (pEMV3 = 0.031, pECDisp3 < 0.001); (4) Conclusions: Pulsatile TM motion reduced in POAG patients relevant to the level of diurnal IOP fluctuation. This study presents the segmental variance of TM stiffness in human living eyes and suggests the clinical potential of the measurement of pulsatile TM motion with PhS-OCT for the evaluation of diurnal IOP fluctuation.
(1) 背景：探讨搏动性小梁网（TM）运动在预测原发性开角型青光眼（POAG）日间眼压（IOP）波动中的价值。(2) 方法：这项横断面研究招募了20名正常患者和30名POAG患者。在POAG组中，20名患者的日间IOP稳定，10名患者的IOP波动较大。使用临床原型相敏光学相干断层扫描（PhS-OCT）模型测量TM的搏动性运动，包括最大速度（MV）和累积位移（CDisp）。(3) 结果：正常人和POAG患者外部区域的MV和CDisp均较高。POAG组中所有MV和CDisp均显著降低（p < 0.001）。在POAG组中，除了外部区域的MV（p = 0.085）外，鼻侧区域的MV和CDisp显著高于颞侧区域（p < 0.05）。IOP波动较大的POAG患者鼻侧区域外部的MV和CDisp远低于IOP稳定的患者（pEMV3 = 0.031，pECDisp3 < 0.001）；(4) 结论：POAG患者的搏动性TM运动与日间IOP波动水平相关而降低。本研究展示了人活体眼中TM硬度的节段性差异，并提示使用PhS-OCT测量搏动性TM运动在评估日间IOP波动方面的临床潜力。
