Cheng Lucille G, Miller David, Pelzman Daniel, Wecht Anna, Hwang Kathleen
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
F S Rep. 2024 Jan 12;5(2):140-144. doi: 10.1016/j.xfre.2024.01.002. eCollection 2024 Jun.
To better understand the impact of sperm morphology on fertility by assessing sperm morphology in a population of known fertile men.
A prospective cohort study.
Fertility center associated with the university.
Healthy men >18 years of age were recruited to provide one semen sample before a vasectomy appointment scheduled between March 2020 and November 2022. Patients were included in the study when they had at least one biologic child and no history of difficulty achieving pregnancy or fertility procedures.
None.
Sperm morphology.
A total of 68 patients (mean age 36.7 years) were included. Thirty-eight (55.9%) patients had 3% or lower normal sperm morphology, including two patients who had 0 normal morphology. The most common morphologic abnormalities were head-shaped defects (n = 59, 84.3%), followed by coiled tails (n = 14, 20.3%). Count, concentration, motility, and progressive motility were normal in >90% of patients.
More than half (55.9%) of fertile male patients had lower than normal sperm morphology in our study. The results of our study further question the clinical relevance of sperm morphology on fertility outcomes and when the current approach in assessing morphology is too strict.
通过评估已知可育男性群体的精子形态，更好地了解精子形态对生育能力的影响。
一项前瞻性队列研究。
与大学相关的生育中心。
招募年龄大于18岁的健康男性，在2020年3月至2022年11月安排的输精管切除术预约前提供一份精液样本。当患者至少有一个亲生孩子且无受孕困难或生育治疗史时，纳入本研究。
无。
精子形态。
共纳入68例患者（平均年龄36.7岁）。38例（55.9%）患者的正常精子形态为3%或更低，其中2例患者正常形态精子为0。最常见的形态异常是头部形状缺陷（n = 59，84.3%），其次是卷曲尾（n = 14，20.3%）。超过90%的患者精子计数、浓度、活力和前向运动能力正常。
在我们的研究中，超过一半（55.9%）的可育男性患者精子形态低于正常水平。我们的研究结果进一步质疑了精子形态对生育结局的临床相关性，以及目前评估形态的方法是否过于严格。
