Jansen W, Bruckner G W, Jansen P
J Int Med Res. 1985;13(1):48-53. doi: 10.1177/030006058501300107.
Seventy-six patients took part in a randomized, comparative study of the efficacy of buflomedil hydrochloride and dihydrogenated ergot alkaloids in the treatment of senile dementia associated with cerebrovascular insufficiency. Efficacy was assessed by the patients' performance in four psychometric tests. The results showed that a trend in favour of the buflomedil group in three of the tests became statistically significant in the fourth. Both drugs appeared to be safe, causing no marked adverse reactions. In conclusion, buflomedil is as effective or more effective than dihydrogenated ergot alkaloids in the treatment of senile dementia associated with cerebrovascular insufficiency and could prove a valuable addition to long-term therapy if further studies support the trend shown in this study.
76名患者参与了一项关于盐酸丁咯地尔和双氢麦角碱治疗与脑血管供血不足相关的老年痴呆症疗效的随机对照研究。通过四项心理测量测试来评估疗效。结果显示，在其中三项测试中丁咯地尔组有优势的趋势在第四项测试中具有统计学意义。两种药物似乎都很安全，未引起明显不良反应。总之，在治疗与脑血管供血不足相关的老年痴呆症方面，丁咯地尔与双氢麦角碱疗效相当或更优，如果进一步研究支持本研究所示趋势，那么它可能成为长期治疗的一种有价值的补充药物。
