Nyman Karl J, Frieling Jeremy S, Lynch Conor C
The Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL, USA.
Department of Tumor Microenvironment and Metastasis, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
J Bone Oncol. 2024 May 17;47:100610. doi: 10.1016/j.jbo.2024.100610. eCollection 2024 Aug.
The skeleton is a common site of cancer metastasis and malignancy with the resultant lesions often being incurable. Interactions between metastatic cancer cells and the bone microenvironment are critical for cancer cell survival, outgrowth, and progression. Mesenchymal Stem Cells (MSCs) are an essential stromal cell type in bone that are appreciated for their impacts on cancer-induced bone disease, however, newer evidence suggests that MSCs possess extensive roles in cancer-bone crosstalk, including cancer cell dormancy, metabolic demands, and immune-oncology. Emerging evidence has also identified the importance of MSC tissue source and the influence of ageing when studying MSC biology. Combining these considerations together with developing technologies such as spatial transcriptomics will contribute to defining the molecular mechanisms underlying complex stroma-cancer interactions in bone and assist with identification of therapeutically tractable targets.
骨骼是癌症转移和恶性肿瘤的常见部位，由此产生的病变往往无法治愈。转移性癌细胞与骨微环境之间的相互作用对于癌细胞的存活、生长和进展至关重要。间充质干细胞（MSCs）是骨骼中一种重要的基质细胞类型，因其对癌症诱导的骨病的影响而受到关注，然而，新的证据表明，间充质干细胞在癌症与骨的相互作用中具有广泛作用，包括癌细胞休眠、代谢需求和免疫肿瘤学。新出现的证据还确定了间充质干细胞组织来源的重要性以及在研究间充质干细胞生物学时衰老的影响。将这些考虑因素与空间转录组学等新兴技术相结合，将有助于确定骨骼中复杂的基质-癌症相互作用的分子机制，并有助于识别可治疗的靶点。
