Sutnga Innocent, Sharma Akash, Chakraborty Raja
Institute of Pharmacy, Assam Don Bosco University, Tapesia Gardens, Sonapur, Assam, 782402, India.
Pharm Nanotechnol. 2024 Jul 9. doi: 10.2174/0122117385304559240626101716.
Cancer is classified as having one of the highest mortality rates on a global scale, presenting a significant challenge in its treatment, especially when conventional chemotherapy methodologies are used. Conversely, there is a growing interest in utilizing herbal medicine as an alternative to the treatment of cancer because of its lack of adverse effects compared to contemporary medical strategies. The incorporation of nanotechnology into therapy has attracted attention owing to its efficacy in the treatment of various illnesses. Phytosomes play a crucial role in the treatment of cancer by enhancing the characteristics of drugs and nanostructures within carriers to enable targeted drug delivery. The establishment of chemical bonds between phospholipid molecules and bioactive compounds from plants ensures the stability of phytosomes, thus establishing them as an innovative mechanism for drug delivery systems that transport plant-derived constituents to specific areas. This mini-overview discusses the potential phytosome complexes, uses, drawbacks, patents, challenges, and prospects of phytosomes in cancer treatment. Thus, numerous phytosomal formulations incorporating plant-derived components have exhibited promising anticancer properties, with several formulations currently undergoing clinical trials.
癌症在全球范围内被归类为死亡率最高的疾病之一，其治疗面临重大挑战，尤其是在使用传统化疗方法时。相反，由于与当代医学策略相比，草药缺乏副作用，因此越来越多的人对利用草药作为癌症治疗的替代方法感兴趣。将纳米技术纳入治疗因其在治疗各种疾病方面的功效而受到关注。植物脂质体通过增强载体中药物和纳米结构的特性以实现靶向给药，在癌症治疗中发挥着关键作用。磷脂分子与植物生物活性化合物之间形成化学键可确保植物脂质体的稳定性，从而使其成为一种创新的药物递送系统机制，可将植物衍生成分运输到特定区域。本简要概述讨论了植物脂质体复合物在癌症治疗中的潜在用途、缺点、专利、挑战和前景。因此，许多含有植物衍生成分的植物脂质体制剂已表现出有前景的抗癌特性，目前有几种制剂正在进行临床试验。
