Raghav Asha, Attri Meenakshi, Chaudhary Hema
School of Medical and Allied Science, K. R. Mangalam University, Gurugram-122103, Haryana, India.
Curr Drug Deliv. 2024 Feb 29. doi: 10.2174/0115672018282264240218034853.
Phytoconstituents have been widely used since ancient times to form a complex with phospholipids due to their various therapeutic actions. Despite having strong pharmacodynamic efficiency, numerous phytoconstituents have shown lower in vivo bioavailability and few adverse effects. Phytochemicals soluble in water exhibit poor absorption, leading to a limited therapeutic impact. Phytosome nanotechnology overcomes this limitation by creating a bound of phytochemicals with phospholipids. This method exhibits improved absorption because phytosomes inhibit significant herbal extract components from being degraded by gastric juices and gut flora. This improves bioavailability, increases clinical benefit, and ensures delivery to tissues without compromising nutritional stability. This review also aims to highlight those vesicular systems that could be used in phytosome technology. Additionally, this review highlights the preparation, advantage, characterization, applications, and recent development of phytosome and ethosome with a list of recent patents and marketed formulations and their uses.
由于其多种治疗作用，植物成分自古以来就被广泛用于与磷脂形成复合物。尽管具有强大的药效学效率，但许多植物成分在体内的生物利用度较低，且不良反应较少。水溶性植物化学物质吸收较差，导致治疗效果有限。植物脂质体纳米技术通过将植物化学物质与磷脂结合来克服这一限制。这种方法具有更好的吸收效果，因为植物脂质体可抑制重要的草药提取物成分被胃液和肠道菌群降解。这提高了生物利用度，增加了临床益处，并确保在不影响营养稳定性的情况下将其输送到组织中。本综述还旨在强调那些可用于植物脂质体技术的囊泡系统。此外，本综述重点介绍了植物脂质体和醇质体的制备、优势、表征、应用及最新进展，列出了近期的专利、上市制剂及其用途。
