Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Cité, Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France.
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Cité, Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France.
Immunity. 2024 Jul 9;57(7):1454-1456. doi: 10.1016/j.immuni.2024.06.007.
The association of tertiary lymphoid structures (TLSs) with survival and immunotherapy response brought B cells to center stage. In a pan-cancer B cells atlas in Science, Ma et al. show that germinal center reaction generating anti-tumor antibody-secreting cells (ASCs) from B memory cells in mature TLSs co-exist in tumors with extra-follicular reaction generating auto-reactive ASCs from memory B cells in immature TLSs.
TLS 与生存和免疫治疗反应相关，这使得 B 细胞成为研究的焦点。在《科学》杂志的一项泛癌种 B 细胞图谱研究中，马等人表明，成熟 TLS 中的 B 记忆细胞产生抗肿瘤抗体分泌细胞（ASC）的生发中心反应与不成熟 TLS 中的记忆 B 细胞产生自身反应性 ASC 的滤泡外反应共存于肿瘤中。
