Department of Laboratory Medicine, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, 130021, PR China.
Department of Laboratory Medicine, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, 130021, PR China.
Am J Med Sci. 2024 Dec;368(6):610-620. doi: 10.1016/j.amjms.2024.07.005. Epub 2024 Jul 8.
Serum uric acid (SUA) may be involved in the development of cancer by inhibiting oxidative stress, but its relationship with breast cancer remains unclear.
The PubMed, Embase, and Web of Science databases were searched systematically for studies on SUA levels in women with breast cancer and the effect of SUA levels on the risk of breast cancer. The Newcastle‒Ottawa Quality Assessment Scale (NOS) was used to assess the quality of all relevant studies included.
A total of 19 studies were included, including 75,827 women with breast cancer and 508,528 healthy controls. A meta-analysis found that SUA levels were negatively correlated with breast cancer risk in women (HR = 0.94, 95% CI: 0.89 - 0.99, p = 0.003). SUA levels in female breast cancer patients were not significantly different from those in healthy controls (SMD = 0.49, 95% CI = -0.09 - 1.08, p = 0.10), while SUA levels were increased in female breast cancer patients in articles published after 2010, SUA concentration detected by spectrophotometry, and non-Asian populations, regardless of menopausal state and treatment state.
High levels of SUA may reduce the risk of breast cancer in women, suggesting that SUA was a protective factor in women.
血清尿酸（SUA）通过抑制氧化应激可能参与癌症的发生，但它与乳腺癌的关系尚不清楚。
系统检索了 PubMed、Embase 和 Web of Science 数据库中关于乳腺癌女性 SUA 水平及其对乳腺癌风险影响的研究。使用纽卡斯尔-渥太华质量评估量表（NOS）评估所有纳入研究的质量。
共纳入 19 项研究，包括 75827 例乳腺癌女性和 508528 例健康对照。荟萃分析发现，SUA 水平与女性乳腺癌风险呈负相关（HR=0.94，95%CI：0.89-0.99，p=0.003）。女性乳腺癌患者的 SUA 水平与健康对照者无显著差异（SMD=0.49，95%CI=-0.09-1.08，p=0.09），但在 2010 年后发表的文章、采用分光光度法检测 SUA 浓度以及非亚洲人群中，女性乳腺癌患者的 SUA 水平升高，无论绝经状态和治疗状态如何。
高水平的 SUA 可能降低女性乳腺癌的风险，表明 SUA 是女性的保护因素。
