Keefe Patrick, Puthanveetil Prasanth
Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA.
Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA.
Nutrients. 2024 Dec 4;16(23):4195. doi: 10.3390/nu16234195.
In this review, we provide an evidence-based approach to determine the cellular and systemic actions of two structurally similar flavonoids, apigenin and chrysin. We have clearly evaluated and charted the overlapping and diverging properties of these two sister flavonoids. Based on two separate Omics-based approaches by our group and independent reports from others, the cholesterol-lowering properties have been revealed. In addition, the prevention of uric acid biosynthesis and enhancement of ketogenesis have also been quite evident in these two flavonoids. Along with these overlapping functions, apigenin and chrysin have also demonstrated unique properties that allow them to stand out from each other. Chrysin has demonstrated abilities like downregulating alanine metabolism and pyrimidine synthesis, which could be helpful in metabolic diseases like cancer. In contrast, apigenin has demonstrated anti-oxidant and anti-inflammatory properties by enhancing endogenous anti-inflammatory lipids and upregulating vasoprotective metabolites, which could be beneficial for cardiovascular, renal, and cerebrovascular complications. Further validation studies using in vivo and translational approaches could provide us with better clarity regarding the use of these agents therapeutically and to treat a combination or pool of metabolic diseases.
在本综述中，我们提供了一种基于证据的方法，以确定两种结构相似的黄酮类化合物芹菜素和白杨素的细胞和全身作用。我们已经明确评估并绘制了这两种姐妹黄酮类化合物的重叠和不同特性。基于我们小组的两种基于组学的独立方法以及其他独立报告，已揭示了它们降低胆固醇的特性。此外，这两种黄酮类化合物在预防尿酸生物合成和增强生酮作用方面也相当明显。除了这些重叠功能外，芹菜素和白杨素还表现出独特的特性，使它们彼此脱颖而出。白杨素已显示出下调丙氨酸代谢和嘧啶合成的能力，这可能对癌症等代谢性疾病有帮助。相比之下，芹菜素通过增强内源性抗炎脂质和上调血管保护代谢物，表现出抗氧化和抗炎特性，这可能对心血管、肾脏和脑血管并发症有益。使用体内和转化方法的进一步验证研究可以为我们在治疗上使用这些药物以及治疗一组或多组代谢性疾病提供更清晰的认识。
