Tanaka N, Christensen P, Rydén S, Klöfver-Ståhl B, Bengmark S
Acta Pathol Microbiol Immunol Scand B. 1985 Jun;93(3):253-4. doi: 10.1111/j.1699-0463.1985.tb02885.x.
The effect of splenectomy in normal rats receiving retrograde intrabiliary (RI) or intravenous (IV) injection of 10(5) Escherichia coli was studied. IV injection of the bacteria did not cause any deaths, independent of whether simultaneous ligation of the common bile duct was performed or not. In contrast, RI injection immediately after splenectomy resulted in the death of 9/12 animals although only 1/12 RI-injected rats with intact spleens died (p less than 0.005). The findings might have implications for the performance of splenectomy in patients with combined hepato-biliary diseases.
研究了脾切除对接受逆行胆管内（RI）或静脉内（IV）注射10⁵大肠杆菌的正常大鼠的影响。静脉注射细菌未导致任何死亡，无论是否同时结扎胆总管。相比之下，脾切除后立即进行RI注射导致9/12的动物死亡，而完整脾脏的RI注射大鼠只有1/12死亡（p<0.005）。这些发现可能对合并肝胆疾病患者的脾切除手术有启示意义。
