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先有座位,再有升级。

First, a seat; then, an upgrade.

机构信息

Nottingham University Hospitals, Derby Rd, Lenton, Nottingham, NG7 2UH, UK.

出版信息

J Hum Hypertens. 2024 Aug;38(8):620-623. doi: 10.1038/s41371-024-00933-2. Epub 2024 Jul 10.

Abstract

The Sir Stanley Peart Essay Competition is an annual event run by the British and Irish Hypertension Society to encourage Early Career Researchers to continue the ethos of Sir Stanley Peart. Sir Stanley Peart was a clinician and clinical researcher who made a major contribution to our understanding of blood pressure regulation. He was the first to demonstrate the release of noradrenaline in response to sympathetic nerve stimulation. He was also the first to purify, and determine the structure of, angiotensin and he later isolated the enzyme, renin, and carried out many important investigations of the factors controlling its release in the body. This year, the essay topic was "Do we need new classes of antihypertensive drugs?". In his prize-winning essay, "First, a seat; then, an upgrade", Dr Sathyanarayanan argues that we do not need new classes of antihypertensive drugs, instead we should focus our attention on addressing the factors that lead to high blood pressure in the first place and use our existing drug classes more effectively.

摘要

斯坦利·皮尔特爵士论文竞赛是由英国和爱尔兰高血压学会主办的年度活动,旨在鼓励早期职业研究人员延续斯坦利·皮尔特爵士的精神。斯坦利·皮尔特爵士是一位临床医生和临床研究员,他为我们对血压调节的理解做出了重大贡献。他是第一个证明去甲肾上腺素在交感神经刺激下释放的人。他也是第一个纯化并确定血管紧张素结构的人,后来他分离出了酶肾素,并对控制其在体内释放的因素进行了许多重要的研究。今年的论文主题是“我们是否需要新的降压药类别?”。在他的获奖论文《首先是座位,然后是升级》中,萨蒂亚纳拉扬博士认为,我们不需要新的降压药类别,相反,我们应该首先关注导致高血压的因素,并更有效地利用我们现有的药物类别。

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