淋巴细胞功能相关抗原-1（LFA-1）在细胞介导杀伤及黏附中的作用：对遗传性LFA-1、巨噬细胞抗原-1（Mac-1）缺陷及淋巴细胞自身聚集的研究 - Suppr

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The function of LFA-1 in cell-mediated killing and adhesion: studies on heritable LFA-1, Mac-1 deficiency and on lymphoid cell self-aggregation.

作者信息

Springer T A, Rothlein R, Anderson D C, Burakoff S J, Krensky A M

出版信息

Adv Exp Med Biol. 1985;184:311-22. doi: 10.1007/978-1-4684-8326-0_21.

DOI:10.1007/978-1-4684-8326-0_21

PMID:3898754

Abstract

摘要

相似文献

The function of LFA-1 in cell-mediated killing and adhesion: studies on heritable LFA-1, Mac-1 deficiency and on lymphoid cell self-aggregation.淋巴细胞功能相关抗原-1（LFA-1）在细胞介导杀伤及黏附中的作用：对遗传性LFA-1、巨噬细胞抗原-1（Mac-1）缺陷及淋巴细胞自身聚集的研究

Adv Exp Med Biol. 1985;184:311-22. doi: 10.1007/978-1-4684-8326-0_21.

Heritable lymphocyte function-associated antigen-1 deficiency: abnormalities of cytotoxicity and proliferation associated with abnormal expression of LFA-1.遗传性淋巴细胞功能相关抗原-1缺陷：与淋巴细胞功能相关抗原-1异常表达相关的细胞毒性和增殖异常。

J Immunol. 1985 Nov;135(5):3102-8.

Lymphocyte function-associated antigens: regulation of lymphocyte adhesions in vitro and immunity in vivo.

Adv Exp Med Biol. 1985;184:291-310. doi: 10.1007/978-1-4684-8326-0_20.

LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function.淋巴细胞功能相关抗原-1（LFA-1）和Lyt-2、3分子，与T淋巴细胞介导的杀伤作用相关；还有巨噬细胞-1（Mac-1），一种与补体受体功能相关的LFA-1同源物。

Immunol Rev. 1982;68:171-95. doi: 10.1111/j.1600-065x.1982.tb01064.x.

The genetic deficiency of leukocyte surface glycoprotein Mac-1, LFA-1, p150,95 in humans is associated with defective antibody-dependent cellular cytotoxicity in vitro and defective protection against herpes simplex virus infection in vivo.人类白细胞表面糖蛋白Mac-1、淋巴细胞功能相关抗原-1（LFA-1）、p150,95的基因缺陷与体外抗体依赖性细胞毒性缺陷以及体内抗单纯疱疹病毒感染保护缺陷相关。

J Immunol. 1986 Sep 1;137(5):1688-94.

Functional interactions of LFA-1, T8 and alloantigen surface structures in T-cell mediated cytotoxicity.

Adv Exp Med Biol. 1985;184:323-41. doi: 10.1007/978-1-4684-8326-0_22.

Abnormal cytolytic activity of lymphocyte function-associated antigen-1-deficient human cytolytic T lymphocyte clones.淋巴细胞功能相关抗原-1缺陷型人细胞毒性T淋巴细胞克隆的异常细胞溶解活性。

J Clin Invest. 1986 Nov;78(5):1387-91. doi: 10.1172/JCI112725.

Blocking of CTL-mediated killing by monoclonal antibodies to LFA-1 and Lyt-2, 3. II. Evidence that trypsin pretreatment of target cells removes a non-H-2 molecule important in killing.用抗淋巴细胞功能相关抗原-1（LFA-1）和抗Lyt-2、3单克隆抗体阻断细胞毒性T淋巴细胞（CTL）介导的杀伤作用。II. 靶细胞经胰蛋白酶预处理可去除杀伤过程中起重要作用的非H-2分子的证据。

J Immunol. 1985 Jan;134(1):70-7.

The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system.淋巴细胞功能相关的淋巴细胞功能相关抗原-1、CD2和淋巴细胞功能相关抗原-3分子：免疫系统的细胞粘附受体。

Annu Rev Immunol. 1987;5:223-52. doi: 10.1146/annurev.iy.05.040187.001255.

Immunologic studies with LFA-1- and Mo1-deficient lymphocytes from a patient with recurrent bacterial infections.对一名复发性细菌感染患者的LFA-1和Mo1缺陷淋巴细胞进行的免疫学研究。

J Immunol. 1985 May;134(5):3075-81.

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ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.利用 CRISPR/Cas9 技术敲除细胞间黏附分子-1（ICAM-1）可通过抑制桩蛋白（paxillin）/粘着斑激酶（FAK）依赖性 Rho GTPase 通路来减轻创伤性脑损伤诱导的炎症性白细胞黏附和迁移级联反应，从而保护大脑。

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LFA-1 in T Cell Migration and Differentiation.LFA-1 在 T 细胞迁移和分化中的作用。

Front Immunol. 2018 May 3;9:952. doi: 10.3389/fimmu.2018.00952. eCollection 2018.

LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.缺乏淋巴细胞功能相关抗原-1（LFA-1）的小鼠对病毒表现出正常的细胞毒性T淋巴细胞（CTL）反应，但无法排斥免疫原性肿瘤。

J Exp Med. 1996 Apr 1;183(4):1415-26. doi: 10.1084/jem.183.4.1415.

J Clin Invest. 1986 Nov;78(5):1387-91. doi: 10.1172/JCI112725.

Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3.中性粒细胞和单核细胞的细胞表面p150,95具有类似于CR3的iC3b受体（CR4）活性。

J Clin Invest. 1988 Aug;82(2):640-51. doi: 10.1172/JCI113643.

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