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化学突触的物理存在对于秀丽隐杆线虫中PLM神经元分支点处顺行突触小泡的转向行为是必要的。

Physical presence of chemical synapses is necessary for turning behavior of anterograde synaptic vesicles at the branch point of PLM neurons in .

作者信息

Vasudevan Amruta, Koushika Sandhya P

机构信息

Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India.

出版信息

MicroPubl Biol. 2024 Jun 25;2024. doi: 10.17912/micropub.biology.001204. eCollection 2024.

DOI:10.17912/micropub.biology.001204
PMID:38989012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11234195/
Abstract

Neurons exhibit complex branched axonal morphologies in both vertebrate and invertebrate systems, and show heterogeneity in the distribution of synaptic cargo across multiple synapses. It is possible that differences in transport across multiple branches contribute to the heterogeneity in cargo distribution across multiple synapses. However, the regulation of transport at axonal branch points is not well understood. We demonstrate that branch-specific transport of synaptic vesicles is dependent on the existence of a connection between the branch and synapses. The loss of this connection causes an immediate decrease in branch-specific transport of synaptic vesicles in the PLM neuron of .

摘要

在脊椎动物和无脊椎动物系统中，神经元都呈现出复杂的分支轴突形态，并且在多个突触间的突触货物分布上表现出异质性。跨多个分支的运输差异可能导致多个突触间货物分布的异质性。然而，轴突分支点处运输的调控机制尚不清楚。我们证明，突触小泡的分支特异性运输依赖于分支与突触之间连接的存在。这种连接的缺失会导致秀丽隐杆线虫PLM神经元中突触小泡的分支特异性运输立即减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b272/11234195/42b73d08bffc/25789430-2024-micropub.biology.001204.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b272/11234195/42b73d08bffc/25789430-2024-micropub.biology.001204.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b272/11234195/42b73d08bffc/25789430-2024-micropub.biology.001204.jpg

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本文引用的文献

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WormBase 2024: status and transitioning to Alliance infrastructure.WormBase 2024：现状及向联盟基础设施的过渡。
Genetics. 2024 May 7;227(1). doi: 10.1093/genetics/iyae050.
2
Preferential transport of synaptic vesicles across neuronal branches is regulated by the levels of the anterograde motor UNC-104/KIF1A in vivo.突触囊泡在神经元分支间的优先转运受到体内正向运动 UNC-104/KIF1A 水平的调控。
Genetics. 2024 May 7;227(1). doi: 10.1093/genetics/iyae021.
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Selective axonal transport through branch junctions is directed by growth cone signaling and mediated by KIF1/kinesin-3 motors.
通过分支连接点的选择性轴突运输是由生长锥信号指导的，并由 KIF1/驱动蛋白-3 马达介导。
Cell Rep. 2022 Apr 26;39(4):110748. doi: 10.1016/j.celrep.2022.110748.
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Sentryn Acts with a Subset of Active Zone Proteins To Optimize the Localization of Synaptic Vesicles in .Sentryn 与一组活性区蛋白共同作用，以优化突触囊泡在. 中的定位。
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