Hsieh Yi-Wen, Alqadah Amel, Chuang Chiou-Fen
Division of Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio.
Genesis. 2014 Jun;52(6):544-54. doi: 10.1002/dvg.22744. Epub 2014 Feb 7.
Asymmetries in the nervous system have been observed throughout the animal kingdom. Deviations of brain asymmetries are associated with a variety of neurodevelopmental disorders; however, there has been limited progress in determining how normal asymmetry is established in vertebrates. In the Caenorhabditis elegans chemosensory system, two pairs of morphologically symmetrical neurons exhibit molecular and functional asymmetries. This review focuses on the development of antisymmetry of the pair of amphid wing "C" (AWC) olfactory neurons, from transcriptional regulation of general cell identity, establishment of asymmetry through neural network formation and calcium signaling, to the maintenance of asymmetry throughout the life of the animal. Many of the factors that are involved in AWC development have homologs in vertebrates, which may potentially function in the development of vertebrate brain asymmetry.
在整个动物界都观察到了神经系统的不对称性。脑不对称性的偏差与多种神经发育障碍有关；然而，在确定脊椎动物中正常不对称性是如何建立的方面进展有限。在秀丽隐杆线虫的化学感应系统中，两对形态对称的神经元表现出分子和功能上的不对称性。本综述重点关注一对两性翼“C”（AWC）嗅觉神经元的反对称性发育，从一般细胞身份的转录调控、通过神经网络形成和钙信号建立不对称性，到动物一生中不对称性的维持。许多参与AWC发育的因素在脊椎动物中有同源物，它们可能在脊椎动物脑不对称性的发育中发挥作用。
