Department of Obstetrics and Gynecology, Obstetrics and Pediatrics Training and Research Hospital, Giresun University, Giresun, Turkey.
Department of Obstetrics and Gynecology, Kanuni Training and Research Hospital, Trabzon, Turkey.
J Matern Fetal Neonatal Med. 2024 Dec;37(1):2371979. doi: 10.1080/14767058.2024.2371979. Epub 2024 Jul 11.
To evaluate neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-monocyte ratio (NMR), and other hemogram-derived inflammatory parameters measured in the early second trimester and their association with the risk of gestational diabetes mellitus (GDM).
This case-control study was conducted with 105 women with GDM and 205 healthy pregnant women, matched for maternal age at a 1:2 ratio with the cases at two regional maternity hospitals between January 2021 and August 2022. The inflammatory blood cell indices were tested in the early second trimester, and the patient's characteristics and the course of the pregnancy were analyzed. Logistic regression was used to determine the association between hematological parameters and the risk of GDM. Data were analyzed using SPSS, version 25.0 (SPSS, Chicago, IL).
The final analysis included 310 pregnant women. The GDM group showed a higher pre-pregnancy BMI compared to the healthy controls ( < .01). There was no difference in NMR, PLR, and NLR between the groups ( = .63, .54, and .39, respectively). GDM was only positively associated with MLR ( = .02). After adjusting for potential confounding risk factors including maternal age, parity, and BMI, the multivariate regression analysis showed a higher level of MLR, with a cutoff point of 0.312, was independently associated with the risk of GDM (OR = 2.15, 95%CI 1.51-4.31, = .03). However, ROC analysis showed that the AUC value of MLR was poor (0.670).
We found that MLR, an inflammatory combined index derived from whole blood counts, may potentially serve as a predictor of GDM in the early second trimester.
评估中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）、中性粒细胞与单核细胞比值（NMR）和其他在孕中期早期测量的血液衍生炎症参数，并探讨其与妊娠期糖尿病（GDM）风险的关系。
本病例对照研究纳入了 2021 年 1 月至 2022 年 8 月期间在两家地区性妇产科医院就诊的 105 例 GDM 患者和 205 例健康孕妇，按照 1:2 的比例匹配母亲年龄。在孕中期早期检测炎症性血细胞指数，并分析患者特征和妊娠过程。采用 logistic 回归确定血液学参数与 GDM 风险之间的关联。使用 SPSS 版本 25.0（SPSS，芝加哥，IL）进行数据分析。
最终分析纳入了 310 名孕妇。GDM 组的孕前 BMI 高于健康对照组（<0.01）。两组间的 NMR、PLR 和 NLR 无差异（=0.63、0.54 和 0.39）。GDM 仅与 MLR 呈正相关（=0.02）。在校正包括母亲年龄、产次和 BMI 等潜在混杂风险因素后，多元回归分析显示，较高水平的 MLR（截断值为 0.312）与 GDM 的风险独立相关（OR=2.15，95%CI 1.51-4.31，=0.03）。然而，ROC 分析显示 MLR 的 AUC 值较差（0.670）。
我们发现，来自全血细胞计数的炎症综合指数 MLR 可能可作为孕中期早期 GDM 的预测指标。
