小鼠胰腺β细胞中混乱且不规则的爆发式电活动。
Chaotic and irregular bursting electrical activity in mouse pancreatic B-cells.
作者信息
Lebrun P, Atwater I
出版信息
Biophys J. 1985 Sep;48(3):529-31. doi: 10.1016/S0006-3495(85)83809-1.
Abstract
The glucose-induced B-cell electrical activity was recorded in islets of Langerhans isolated from Swiss Webster albino mice originating from different suppliers. 23 out of 25 islets obtained from mice bred at the Charles River Breeding Station (CR mice) exhibited irregular or chaotic burst patterns of electrical activity, while 36 out of 40 islets isolated from mice bred locally at the National Institutes of Health displayed the typical bursting activity. The CR mice tended to recover a regular pattern after 1 mo on the National Institutes of Health mouse diet. The irregular or chaotic bursting electrical activity is proposed to result from changes in B-cell membrane composition or cellular metabolism, possibly induced by differences in diet.
摘要
记录了从不同供应商处获得的瑞士韦伯斯特白化小鼠分离出的胰岛中葡萄糖诱导的B细胞电活动。从查尔斯河繁殖站（CR小鼠）饲养的小鼠中获得的25个胰岛中有23个表现出不规则或混乱的电活动爆发模式，而从国立卫生研究院本地饲养的小鼠中分离出的40个胰岛中有36个表现出典型的爆发活动。CR小鼠在食用国立卫生研究院小鼠饮食1个月后倾向于恢复规律模式。有人提出，不规则或混乱的爆发性电活动是由B细胞膜组成或细胞代谢的变化引起的，可能是由饮食差异诱导的。
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