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本文引用的文献

1
The influence of a hypercalric diet on gross body and adipose tissue composition in the rat.高热量饮食对大鼠总体重及脂肪组织组成的影响。
J Nutr. 1962 Jun;77(2):187-97. doi: 10.1093/jn/77.2.187.
2
The nature of the oscillatory behaviour in electrical activity from pancreatic beta-cell.胰腺β细胞电活动中振荡行为的本质。
Horm Metab Res Suppl. 1980;Suppl 10:100-7.
3
Cyclic variations of glucose-induced electrical activity in pancreatic B cells.
Pflugers Arch. 1982 Jun;393(4):322-7. doi: 10.1007/BF00581418.
4
The topography of electrical synchrony among beta-cells in the mouse islet of Langerhans.小鼠胰岛中β细胞间电同步的拓扑结构。
Q J Exp Physiol. 1984 Oct;69(4):719-35.
5
Modification of cell membrane composition by dietary lipids and its implications for atherosclerosis.膳食脂质对细胞膜组成的改变及其对动脉粥样硬化的影响。
Ann N Y Acad Sci. 1983;414:29-43. doi: 10.1111/j.1749-6632.1983.tb31672.x.
6
Isolated islets of Langerhans have slow oscillations of electrical activity.分离的胰岛具有缓慢的电活动振荡。
Metabolism. 1983 Jul;32(7):681-5. doi: 10.1016/0026-0495(83)90124-5.
7
Bursting, beating, and chaos in an excitable membrane model.兴奋性膜模型中的爆发、搏动和混沌现象。
Biophys J. 1985 Mar;47(3):357-66. doi: 10.1016/S0006-3495(85)83926-6.

小鼠胰腺β细胞中混乱且不规则的爆发式电活动。

Chaotic and irregular bursting electrical activity in mouse pancreatic B-cells.

作者信息

Lebrun P, Atwater I

出版信息

Biophys J. 1985 Sep;48(3):529-31. doi: 10.1016/S0006-3495(85)83809-1.

DOI:10.1016/S0006-3495(85)83809-1
PMID:3899208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1329367/
Abstract

The glucose-induced B-cell electrical activity was recorded in islets of Langerhans isolated from Swiss Webster albino mice originating from different suppliers. 23 out of 25 islets obtained from mice bred at the Charles River Breeding Station (CR mice) exhibited irregular or chaotic burst patterns of electrical activity, while 36 out of 40 islets isolated from mice bred locally at the National Institutes of Health displayed the typical bursting activity. The CR mice tended to recover a regular pattern after 1 mo on the National Institutes of Health mouse diet. The irregular or chaotic bursting electrical activity is proposed to result from changes in B-cell membrane composition or cellular metabolism, possibly induced by differences in diet.

摘要

记录了从不同供应商处获得的瑞士韦伯斯特白化小鼠分离出的胰岛中葡萄糖诱导的B细胞电活动。从查尔斯河繁殖站（CR小鼠）饲养的小鼠中获得的25个胰岛中有23个表现出不规则或混乱的电活动爆发模式，而从国立卫生研究院本地饲养的小鼠中分离出的40个胰岛中有36个表现出典型的爆发活动。CR小鼠在食用国立卫生研究院小鼠饮食1个月后倾向于恢复规律模式。有人提出，不规则或混乱的爆发性电活动是由B细胞膜组成或细胞代谢的变化引起的，可能是由饮食差异诱导的。