Department of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.
Zhejiang Provincial Clinical Research Center for Pediatric Disease, The Second School of Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
BMC Public Health. 2024 Jul 11;24(1):1858. doi: 10.1186/s12889-024-19078-5.
Spontaneous abortion is a common complication of pregnancy that can lead to adverse physical and psychological outcomes for women. Vitamin D is reported to be associated with reproductive functions, whereas its casual effects on abortion remains unclear.
In this study, a two-sample Mendelian randomization (MR) analysis was performed to systematically assess the causal relationships between serum 25 hydroxyvitamin D [25(OH)D] concentration and the risk of spontaneous abortion. GWAS summary data of 25(OH)D were used as exposure, and data of spontaneous abortion was considered as outcome. A retrospective study was additionally conducted to verify the MR results.
MR estimates showed that a higher 25(OH)D level was potentially associated with decreased risk of spontaneous abortion (IVW, OR = 0.98, 95%CI = 0.90-1.06; MR Egger, OR = 0.94, 95%CI = 0.84-1.05; Weighted median, OR = 0.93, 95%CI = 0.82-1.06; Weighted mode, OR = 0.93, 95%CI = 0.84-1.03), though the P-value was not statistically significant. The retrospective study also produced consistent result of Vitamin D's protective role to spontaneous abortion. The P-value was very close to statistical significance (P = 0.053).
This study reports the potential protective role of serum 25(OH)D concentration to spontaneous abortion, suggesting that increased vitamin D levels may decrease the risk of abortion. Further larger prospective studies and/or even randomized controlled trials are needed to confirm causal relationship between vitamin D and abortion.
自然流产是妊娠的常见并发症，可导致女性身体和心理不良后果。维生素 D 被报道与生殖功能有关，但其与流产的因果关系尚不清楚。
本研究采用两样本 Mendelian randomization (MR) 分析系统评估血清 25 羟维生素 D [25(OH)D] 浓度与自然流产风险之间的因果关系。GWAS 汇总了 25(OH)D 的数据作为暴露，自然流产的数据被认为是结局。此外，还进行了一项回顾性研究来验证 MR 结果。
MR 估计表明，较高的 25(OH)D 水平可能与自然流产风险降低相关（IVW，OR=0.98，95%CI=0.90-1.06；MR Egger，OR=0.94，95%CI=0.84-1.05；加权中位数，OR=0.93，95%CI=0.82-1.06；加权众数，OR=0.93，95%CI=0.84-1.03），尽管 P 值无统计学意义。回顾性研究也得出了维生素 D 对自然流产具有保护作用的一致结果。P 值非常接近统计学意义（P=0.053）。
本研究报告了血清 25(OH)D 浓度对自然流产的潜在保护作用，提示增加维生素 D 水平可能降低流产风险。需要进一步开展更大规模的前瞻性研究和/或随机对照试验来确认维生素 D 与流产之间的因果关系。
