Bai Ru-Xia, Tang Zou-Ying
Department of Reproductive Medicine, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China.
Exp Ther Med. 2021 Jan;21(1):41. doi: 10.3892/etm.2020.9473. Epub 2020 Nov 17.
Spontaneous abortion (SA) is the most frequently occurring pregnancy disorder and is a serious threat to women's health. Identifying novel risk factors and the molecular mechanisms underlying SA are important. The present study reported that the RNA expression levels of long non-coding RNA H19 were lower in SA group compared with those in the control group, and the expression of was increased and levels of and phospholipid hydroperoxide glutathione peroxidase ( were decreased in SA group at both the mRNA and protein levels. H19 expression was positively correlated with and expression and negatively linked with levels. It was demonstrated that silencing H19 downregulated and expression and upregulated expression at both the mRNA and protein levels in HTR-8/SVneo trophoblast cells. In conclusion, the present findings suggested that H19 has important roles in SA by promoting apoptosis and ferroptosis.
自然流产（SA）是最常见的妊娠疾病，对女性健康构成严重威胁。识别新的风险因素以及SA潜在的分子机制很重要。本研究报道，与对照组相比，SA组中长链非编码RNA H19的RNA表达水平较低，且SA组中[此处原文有缺失内容]的表达在mRNA和蛋白质水平均升高，而[此处原文有缺失内容]和磷脂氢过氧化物谷胱甘肽过氧化物酶（[此处原文有缺失内容]）的水平在mRNA和蛋白质水平均降低。H19表达与[此处原文有缺失内容]和[此处原文有缺失内容]表达呈正相关，与[此处原文有缺失内容]水平呈负相关。结果表明，在HTR-8/SVneo滋养层细胞中，沉默H19在mRNA和蛋白质水平均下调[此处原文有缺失内容]和[此处原文有缺失内容]表达，并上调[此处原文有缺失内容]表达。总之，本研究结果提示H19通过促进细胞凋亡和铁死亡在SA中发挥重要作用。
