Mahmood Aqeel S, Ahmed Abbas Mohammed, Gany Yassin Ammar, Ahmed Haider A, Sabri Samer, Shakir Ahmed A, Abbas Hussein, Ismail Mustafa
Department of Surgery, College of Medicine, University of Baghdad, Baghdad, IRQ.
Department of Biochemistry, College of Medicine, University of Karbala, Karbala, IRQ.
Cureus. 2024 Jun 11;16(6):e62174. doi: 10.7759/cureus.62174. eCollection 2024 Jun.
Surgical intervention for rectal cancer is widely recognized for its potential to significantly impact quality of life, chiefly due to the high probability of permanent colostomy and the associated postoperative complications.
This study aimed to evaluate the short-term outcomes and morbidity associated with total mesorectal excision for middle and lower rectal cancer within an Iraqi cohort, in a prospective setting.
This study prospectively collected and analyzed data from 89 patients who underwent a standardized radical rectal resection, with a follow-up period extending to one month post-surgery.
The mean age of patients was 54.4 ± 12.9 years, with a gender distribution of 46 males and 43 females. A total of 33 patients presented with preoperative comorbidities, which heightened the risk of adverse short-term outcomes by a factor of 7.51. The most prevalent comorbidities were hypertension and diabetes mellitus, affecting 22 and 20 patients, respectively. Patients aged 60 years and above were at a 3.97 times greater risk of developing complications. The overall complication rate was 21.35%, with wound infections (9.0%) and cardiovascular events (3.4%) being the most common. Mortality during the follow-up was 1.1%.
The findings indicate that increased age and the presence of comorbidities are significant risk factors for morbidity and mortality post-surgery. Neoadjuvant chemoradiotherapy or radiotherapy was shown to reduce morbidity and mortality rates while improving survival. The morbidity and mortality rates observed in this study concur with existing literature.
直肠癌的手术干预因其对生活质量有重大影响而被广泛认可，这主要是由于永久性结肠造口术的可能性很高以及相关的术后并发症。
本研究旨在前瞻性地评估伊拉克队列中中下直肠癌全直肠系膜切除术的短期结局和发病率。
本研究前瞻性收集并分析了89例行标准化根治性直肠切除术患者的数据，随访期延长至术后1个月。
患者的平均年龄为54.4±12.9岁，性别分布为男性46例，女性43例。共有33例患者术前存在合并症，这使短期不良结局的风险增加了7.51倍。最常见的合并症是高血压和糖尿病，分别影响22例和20例患者。60岁及以上的患者发生并发症的风险高3.97倍。总体并发症发生率为21.35%，伤口感染（9.0%）和心血管事件（3.4%）最为常见。随访期间的死亡率为1.1%。
研究结果表明，年龄增长和合并症的存在是术后发病和死亡的重要危险因素。新辅助放化疗或放疗可降低发病率和死亡率，同时提高生存率。本研究观察到的发病率和死亡率与现有文献一致。
