Wang Xiuwen, Liu Xuan, Song Kaixuan, Du Liang
State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Front Plant Sci. 2024 Jun 27;15:1396634. doi: 10.3389/fpls.2024.1396634. eCollection 2024.
Ubiquitination is a highly conserved and dynamic post-translational modification in which protein substrates are modified by ubiquitin to influence their activity, localization, or stability. Deubiquitination enzymes (DUBs) counter ubiquitin signaling by removing ubiquitin from the substrates. Ubiquitin-specific proteases (UBPs), the largest subfamily of DUBs, are conserved in plants, serving diverse functions across various cellular processes, although members within the same group often exhibit functional redundancy. Here, we briefly review recent advances in understanding the biological roles of UBPs, particularly the molecular mechanism by which UBPs regulate plant development and growth, morphogenesis, and stress response, which sheds light on the mechanistic roles of deubiquitination in plants.
泛素化是一种高度保守且动态的翻译后修饰，其中蛋白质底物通过泛素进行修饰，以影响其活性、定位或稳定性。去泛素化酶（DUBs）通过从底物上去除泛素来对抗泛素信号。泛素特异性蛋白酶（UBPs）是DUBs中最大的亚家族，在植物中保守，在各种细胞过程中发挥多种功能，尽管同一组内的成员通常表现出功能冗余。在这里，我们简要回顾了在理解UBPs生物学作用方面的最新进展，特别是UBPs调节植物发育和生长、形态发生以及应激反应的分子机制，这为去泛素化在植物中的机制作用提供了线索。
