一种针对过氧化物酶体的人类自身抗体。
A human autoantibody to peroxisomes.
作者信息
Holm R, Gaarder P I, Helgeland L, Falkenhaug E I
出版信息
Clin Exp Immunol. 1985 Aug;61(2):305-14.
A complement fixing, non-organ specific IgG autoantibody is described in 29 patients. The autoantibody gives a highly characteristic, granular staining of liver cells, proximal kidney tubules and stomach surface epithelium. By studies with various subcellular fractions from rat liver, employing two different techniques (quantitative complement fixation, and absorption combined with indirect immunofluorescence) the autoantibody was shown to react with a peroxisomal antigen. No convincing clinical correlations were found.
在29例患者中发现了一种补体结合、非器官特异性的IgG自身抗体。该自身抗体对肝细胞、近端肾小管和胃表面上皮呈现高度特征性的颗粒状染色。通过使用两种不同技术（定量补体结合以及吸收结合间接免疫荧光）对大鼠肝脏的各种亚细胞组分进行研究，发现该自身抗体与一种过氧化物酶体抗原发生反应。未发现令人信服的临床相关性。
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