一种与甲状腺和胃自身免疫相关且可能与肾小管性酸中毒有关的针对肾集合管细胞的人类自身抗体。
A human autoantibody to renal collecting duct cells associated with thyroid and gastric autoimmunity and possibly renal tubular acidosis.
作者信息
Gaarder P I, Heier H E
出版信息
Clin Exp Immunol. 1983 Jan;51(1):29-37.
Abstract
A complement fixing autoantibody reacting with certain renal collecting duct cells, possibly so called dark cells, is described in 113 patients. Clinically, the antibody was strongly associated with thyroid disorders and pernicious anaemia. The patients also showed a markedly increased frequency of thyroid antibodies and antibodies to gastric parietal cells and to intrinsic factor. One of the patients had a distal renal tubular acidosis (RTA) and pernicious anaemia. The antibody was also found in all of three other patients with either latent or manifest RTA. RTA is associated with various immunological diseases, and the renal collecting duct cell antibody may turn out to be a marker of this disorder, either involved in its pathogenesis or representing a secondary phenomenon.
摘要
在113例患者中发现了一种与某些肾集合管细胞（可能是所谓的暗细胞）发生反应的补体结合自身抗体。临床上，该抗体与甲状腺疾病和恶性贫血密切相关。这些患者还表现出甲状腺抗体、胃壁细胞抗体和内因子抗体的频率明显增加。其中一名患者患有远端肾小管酸中毒（RTA）和恶性贫血。在另外三名患有潜伏性或显性RTA的患者中也发现了这种抗体。RTA与多种免疫性疾病有关，肾集合管细胞抗体可能是这种疾病的一个标志物，要么参与其发病机制，要么代表一种继发现象。
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