Faculty of Medicine, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil.
Institute of Biological Science, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Food Funct. 2024 Jul 29;15(15):7757-7781. doi: 10.1039/d4fo00660g.
Glyphosate is the most commercialized herbicide in Brazil and worldwide, and this has become a worrying scenario in recent years. In 2015 glyphosate was classified as potentially carcinogenic by the World Health Organization, which opened avenues for numerous debates about its safe use regarding non-target species' health, including humans. This review aimed to observe the impacts of glyphosate and its formulations on the gut microbiota, as well as on the gut microstructure and animal metabolism. A systematic review was conducted based on the PRISMA recommendations, and the search for original articles was performed in Pubmed/Medline, Scopus and Web of Science databases. The risk of bias in the studies was assessed using the SYRCLE strategy. Our findings revealed that glyphosate and its formulations are able to induce intestinal dysbiosis by altering bacterial metabolism, intestinal permeability, and mucus secretion, as well as causing damage to the microvilli and the intestinal lumen. Additionally, immunological, enzymatic and genetic changes were also observed in the animal models. At the metabolic level, damage was observed in lipid and energy metabolism, the circulatory system, cofactor and vitamin metabolism, and replication, repair, and translation processes. In this context, we pointed out that the studies revealed that these alterations, caused by glyphosate-based herbicides, can lead to intestinal and systemic diseases, such as Crohn's disease and Alzheimer's disease.
草甘膦是巴西乃至全球应用最广泛的除草剂，近年来这已成为一个令人担忧的情况。2015 年，世界卫生组织将草甘膦归类为潜在致癌物质，这引发了关于其在非靶标物种（包括人类）健康方面安全使用的大量争论。本综述旨在观察草甘膦及其制剂对肠道微生物群、肠道微观结构和动物代谢的影响。根据 PRISMA 建议进行了系统评价，在 Pubmed/Medline、Scopus 和 Web of Science 数据库中搜索原始文章。使用 SYRCLE 策略评估研究中的偏倚风险。我们的研究结果表明，草甘膦及其制剂能够通过改变细菌代谢、肠道通透性和黏液分泌来诱导肠道菌群失调，并导致微绒毛和肠腔受损。此外，在动物模型中还观察到免疫、酶和遗传变化。在代谢水平上，观察到脂质和能量代谢、循环系统、辅助因子和维生素代谢以及复制、修复和翻译过程受到损害。在这种情况下，我们指出，这些由草甘膦除草剂引起的改变可能导致肠道和全身性疾病，如克罗恩病和阿尔茨海默病。
