Wang Si-Wei, Zhang Jianzhong, Deng Zhoubin, Lv Yuyu, Huang Danfeng, Wang Ke-Hu, Wang JunJiao, Hu Yulai
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
J Org Chem. 2024 Aug 2;89(15):10591-10602. doi: 10.1021/acs.joc.4c00828. Epub 2024 Jul 12.
A concise and efficient method for the construction of fully substituted difluoromethylpyrazoles is achieved by a cyclization reaction between difluoroacetohydrazonoyl bromides and 2-acylacetonitrile or malononitrile. The method features advantages such as mild reaction conditions, broad substrate scope, good product yields, and high regioselectivity.
通过二氟乙酰腙酰溴与2-酰基乙腈或丙二腈之间的环化反应，实现了一种简洁高效的构建全取代二氟甲基吡唑的方法。该方法具有反应条件温和、底物范围广、产物收率高和区域选择性高的优点。
