Li Jiefang, Xu Shanshan, Liang Jieyu, Zheng Juanjuan, Li Ping, Wang Jun, Li Bin
School of Environmental and Chemical Engineering, Wuyi University, Jiangmen, Guangdong 529020, People's Republic of China.
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region of People's Republic of China.
Org Lett. 2024 Jul 26;26(29):6142-6147. doi: 10.1021/acs.orglett.4c01949. Epub 2024 Jul 12.
Selective dehydrogenative C-H silylation is one of the most powerful tools to synthesize silacycles. Herein, we developed Ru-catalyzed sequential hydrosilylation/C-H silylation of allyl-indoles and dehydrogenative O-H/C-H silylation of pyrrole phenols. Both six-membered indole silacycles and pyrrole silyl ether cycles were successfully synthesized with good functional group tolerance. Furthermore, the RuHCl(CO)(PPh) catalyst exhibited high reaction compatibility in hydrosilylation of alkene, dehydrogenative O-H silylation, and C-H silylation.
选择性脱氢C-H硅基化是合成硅杂环的最有效工具之一。在此，我们开发了钌催化的烯丙基吲哚的连续硅氢化/C-H硅基化反应以及吡咯酚的脱氢O-H/C-H硅基化反应。六元吲哚硅杂环和吡咯硅醚环均成功合成，且具有良好的官能团耐受性。此外，RuHCl(CO)(PPh)催化剂在烯烃的硅氢化、脱氢O-H硅基化和C-H硅基化反应中表现出高反应兼容性。
