钌催化的分子间脱氢O-H/Si-H/C-H硅氢化反应：（）-烯基硅醚和硅醚杂环的合成

Huang Ziwei, Lin Qiao, Li Jiefang, Xu Shanshan, Lv Shaohuan, Xie Feng, Wang Jun, Li Bin

School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.

Guangdong Wamo New Material Technology Co., Ltd., Jiangmen 529020, China.

Molecules. 2023 Oct 20;28(20):7186. doi: 10.3390/molecules28207186.

Selective dehydrogenative silylation is one of the most valuable tools for synthesizing organosilicon compounds. In this study, a regio- and stereoselective ruthenium-catalyzed dehydrogenative intermolecular silylation was firstly developed to access ()-alkenyl silyl-ether derivatives and silyl-ether heterocycles with good functional group tolerance. Furthermore, two pathways for RuH(CO)(PPh)/NBE-catalyzed dehydrogenative intermolecular silylation of alcohols and alkenes as well as intermolecular silylation of naphthol derivatives were investigated with HSiEt as the hydrosilane reagent.

选择性脱氢硅烷化是合成有机硅化合物最有价值的工具之一。在本研究中，首次开发了一种区域和立体选择性的钌催化分子间脱氢硅烷化反应，以制备具有良好官能团耐受性的（）-烯基硅醚衍生物和硅醚杂环。此外，以HSiEt为硅烷试剂，研究了RuH(CO)(PPh)/NBE催化的醇和烯烃分子间脱氢硅烷化以及萘酚衍生物分子间硅烷化的两条途径。