Ashby J, Purchase I F
Environ Mutagen. 1985;7(5):747-58. doi: 10.1002/em.2860070512.
A speculative analysis is presented of the in vitro genotoxicity data reported by Shelby and Stasiewicz for 70 chemicals defined as noncarcinogenic to rodents by the National Toxicology Program. It is concluded that the genotoxic activities observed are probably subject to logical explanation. It is suggested that short-term genotoxicity assays conducted in vivo on newly defined in vitro genotoxins may have a useful role to play in discriminating animal carcinogens from noncarcinogens. It is clear from the results reported that genotoxic activities observed in vitro for a new test chemical only provide evidence of its possible animal carcinogenicity; they are not definitive of carcinogenicity--the difference may be negligible in general but might prove unacceptable in the particular.
对谢尔比和斯塔西维茨报告的70种被美国国家毒理学计划定义为对啮齿动物无致癌性的化学物质的体外遗传毒性数据进行了推测性分析。得出的结论是，观察到的遗传毒性活性可能有合理的解释。建议对新定义的体外遗传毒素进行体内短期遗传毒性试验，这在区分动物致癌物和非致癌物方面可能发挥有益作用。从报告的结果可以清楚地看出，新测试化学物质在体外观察到的遗传毒性活性仅提供了其可能具有动物致癌性的证据；它们并不能确定致癌性——一般来说差异可能微不足道，但在特定情况下可能被证明是不可接受的。
