Rosenkranz H S, Ennever F K
Department of Environmental Health Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106.
Mutat Res. 1988 May-Aug;205(1-4):59-67. doi: 10.1016/0165-1218(88)90009-2.
Since the ability to induce genotoxicity is often equated with the potential for initiating the carcinogenic process, a method for quantitating genotoxicity would provide a useful measure for this potential. It is demonstrated herein that CPBS, the Carcinogenicity Prediction and Battery Selection method, provides a useful quantitative measure of genotoxicity as well as allowing for the detailed evaluation of the performance of batteries of short-term tests in order to select those predictive of carcinogenic potential.
由于诱导基因毒性的能力通常被等同于引发致癌过程的可能性，因此一种定量基因毒性的方法将为这种可能性提供一种有用的衡量标准。本文证明，致癌性预测与试验组合选择方法（CPBS）不仅提供了一种有用的基因毒性定量衡量标准，还能对短期试验组合的性能进行详细评估，以便选择那些能够预测致癌潜力的试验。
