College of Science, University of Thi-Qar.
Ministry of Education, Directorate of Education.
Vopr Virusol. 2024 Jul 5;69(3):266-276. doi: 10.36233/0507-4088-236.
COVID-19 is strongly linked to cardiovascular disease, with direct myocardial injury and systemic inflammation as common mechanisms. Pre-existing or infection-induced cardiovascular disease worsens the outcomes for COVID-19 patients.
To estimate the serum electrolytes (Na, K, Ca, Zn) and vitamin D, the study depended on ichroma ii device for Vitamin D and Chemistry Analyzer for electrolytes in patient samples.
A study was conducted on 192 individuals diagnosed with COVID-19, including 35 critical cases, 53 severe cases, 54 moderate cases, and 50 individuals in a control group. The age group with the highest prevalence of infection was between 50‒69 years, while the lowest prevalence was observed in those under 30 years. The study found significant decreases in calcium, potassium, sodium, zinc, and vitamin D levels among COVID-19 patients compared to the control group. Zinc and vitamin D levels showed a significant correlation with sex, with males experiencing a decline in zinc levels and females having lower vitamin D levels. The concentration of calcium, sodium, and zinc showed a negative correlation with age, with older patients having the lowest levels. COVID-19 patients with chronic cardiac issues and high blood pressure exhibited the lowest levels of these markers. The severity of the disease also had a detrimental impact on electrolyte levels, zinc, and vitamin D, with critical cases showing the lowest levels. The complications such as heart failure were associated with lower levels of potassium, sodium, and zinc.
In conclusion, the study revealed significant associations between COVID-19 and decreased electrolyte levels, zinc, and vitamin D. Sex and age were found to be correlated with these markers. Patients with chronic cardiac issues and high blood pressure exhibited the lowest levels of these markers. The severity of the disease was also linked to lower electrolyte levels, zinc, and vitamin D. Complications such as heart failure were associated with decreased levels of potassium, sodium, and zinc.
COVID-19 与心血管疾病密切相关，其常见机制包括直接心肌损伤和全身炎症。预先存在或感染引起的心血管疾病会使 COVID-19 患者的预后恶化。
为了估计血清电解质（钠、钾、钙、锌）和维生素 D，该研究依赖于 ichroma ii 设备进行维生素 D 检测和化学分析仪进行电解质检测。
对 192 例 COVID-19 患者进行了研究，其中包括 35 例危重症病例、53 例重症病例、54 例中度病例和 50 例对照组。感染率最高的年龄组为 50-69 岁，而 30 岁以下感染率最低。研究发现 COVID-19 患者的钙、钾、钠、锌和维生素 D 水平明显低于对照组。锌和维生素 D 水平与性别呈显著相关性，男性锌水平下降，女性维生素 D 水平较低。钙、钠和锌的浓度与年龄呈负相关，年龄较大的患者水平最低。患有慢性心脏问题和高血压的 COVID-19 患者这些标志物的水平最低。疾病的严重程度也对电解质水平、锌和维生素 D 产生了不利影响，危重症病例的水平最低。心力衰竭等并发症与钾、钠和锌水平降低有关。
综上所述，该研究揭示了 COVID-19 与电解质水平、锌和维生素 D 降低之间存在显著关联。性别和年龄与这些标志物相关。患有慢性心脏问题和高血压的患者这些标志物的水平最低。疾病的严重程度也与较低的电解质水平、锌和维生素 D 有关。心力衰竭等并发症与钾、钠和锌水平降低有关。
