Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, United States; Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States.
Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Cancer Epidemiol. 2024 Oct;92:102611. doi: 10.1016/j.canep.2024.102611. Epub 2024 Jul 13.
Breast cancer is the most common cancer diagnosed among women globally and in the United States (US); however, its incidence in the six US-Affiliated Pacific Islands (USAPI) remains less characterized.
We analyzed data from a population-based cancer registry using different population estimates to calculate incidence rates for breast cancer among women aged >20 years in the USAPI. Rate ratios and 95 % confidence intervals (CI) were calculated to compare incidence rates between the USAPI and the US (50 states and the District of Columbia).
From 2007-2020, 1118 new cases of breast cancer were diagnosed in the USAPI, with 66.3 % (n = 741) of cases reported in Guam. Age-standardized incidence rates ranged from 66.4 to 68.7 per 100,000 women in USAPI and 101.1-110.5 per 100,000 women in Guam. Compared to the US, incidence rates were lower in USAPI, with rate ratios ranging from 0.38 (95 % CI: 0.36, 0.40) to 0.39 (95 % CI: 0.37, 0.42). The proportion of late-stage cancer was significantly higher in the USAPI (48.7 %) than in the US (34.0 %), particularly in the Federated States of Micronesia (78.7 %) and Palau (73.1 %).
Breast cancer incidence rates were lower in the USAPI than in the US; however, late-stage diagnoses were disproportionately higher. Low incidence and late-stage cancers may signal challenges in screening, cancer surveillance, and health care access and resources. Expanding access to timely breast cancer screening, diagnosis, and treatment could reduce the proportion of late-stage cancers and improve survival in the USAPI.
乳腺癌是全球和美国（US）女性中最常见的癌症诊断；然而，其在六个美属太平洋岛屿（USAPI）的发病率仍不明确。
我们使用不同的人口估计值分析了基于人群的癌症登记处的数据，以计算 USAPI 中年龄大于 20 岁的女性乳腺癌的发病率。计算率比和 95%置信区间（CI）以比较 USAPI 和美国（50 个州和哥伦比亚特区）之间的发病率。
2007-2020 年，USAPI 诊断出 1118 例新的乳腺癌病例，其中 66.3%（n=741）报告在关岛。年龄标准化发病率在 USAPI 范围内为每 100,000 名妇女 66.4-68.7 例，在关岛为每 100,000 名妇女 101.1-110.5 例。与美国相比，USAPI 的发病率较低，率比范围为 0.38（95%CI：0.36，0.40）至 0.39（95%CI：0.37，0.42）。晚期癌症的比例在美国 API 中明显高于美国（48.7%），特别是在密克罗尼西亚联邦（78.7%）和帕劳（73.1%）。
USAPI 的乳腺癌发病率低于美国；然而，晚期诊断的比例过高。发病率低和晚期癌症可能表明筛查、癌症监测以及卫生保健获取和资源方面存在挑战。扩大及时进行乳腺癌筛查、诊断和治疗的机会可以降低晚期癌症的比例并改善 USAPI 的生存率。
