Sasaki Tamlyn, Liyanage Akash, Bansil Surbhi, Silva Anthony, Pagano Ian, Hidalgo Elena Y, Jones Corinne, Ueno Naoto T, Takahashi Yoko, Fukui Jami
John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI 96813, USA.
Translational and Clinical Research Program, University of Hawai'i Cancer Center, Honolulu, HI 96813, USA.
Cancers (Basel). 2024 Oct 12;16(20):3462. doi: 10.3390/cancers16203462.
Differences in the incidence of breast cancer subtypes among racial/ethnic groups have been evaluated as a contributing factor in disparities seen in breast cancer prognosis. We evaluated new breast cancer cases in Hawai'i to determine if there were subtype differences according to race/ethnicity that may contribute to known disparities.
We reviewed 4591 cases of women diagnosed with breast cancer from two large tumor registries between 2015 and 2022. We evaluated breast cancer cases according to age at diagnosis, self-reported race, breast cancer subtype (ER, PR, and HER2 receptor status), histology, county, and year.
We found both premenopausal and postmenopausal Native Hawaiian women were less likely to be diagnosed with triple-negative breast cancer (OR = 0.26, 95% CI 0.12-0.58 = 0.001; OR = 0.54, 95% CI 0.36, 0.80 = 0.002, respectively).
The results of our study support that there are racial/ethnic differences in breast cancer subtypes among our population, which may contribute to differences in outcomes. Further evaluation of clinical and pathological features in each breast cancer subtype may help improve the understanding of outcome disparities seen among different racial/ethnic groups.
种族/族裔群体之间乳腺癌亚型发病率的差异已被评估为乳腺癌预后差异的一个促成因素。我们评估了夏威夷的新乳腺癌病例，以确定是否存在根据种族/族裔划分的亚型差异，这些差异可能导致已知的差异。
我们回顾了2015年至2022年间来自两个大型肿瘤登记处的4591例被诊断为乳腺癌的女性病例。我们根据诊断时的年龄、自我报告的种族、乳腺癌亚型（雌激素受体、孕激素受体和人表皮生长因子受体2受体状态）、组织学、县和年份对乳腺癌病例进行了评估。
我们发现绝经前和绝经后的夏威夷原住民女性被诊断为三阴性乳腺癌的可能性较小（优势比分别为0.26，95%置信区间0.12 - 0.58，P = 0.001；优势比为0.54，95%置信区间0.36，0.80，P = 0.002）。
我们的研究结果支持我们人群中乳腺癌亚型存在种族/族裔差异，这可能导致预后差异。对每种乳腺癌亚型的临床和病理特征进行进一步评估可能有助于更好地理解不同种族/族裔群体之间的预后差异。
