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Prognostic and therapeutic implications of TP53 expression in chronic myelomonocytic leukemia.

作者信息

Wang Yu-Hung, Lin Chien-Chin, Gurashi Kristian, Yao Chi-Yuan, Jerez Andres, Hou Hsin-An, Chou Wen-Chien, Tien Hwei-Fang, Batta Kiran, Wiseman Daniel H

机构信息

Division of Cancer Sciences, Epigenetics of Haematopoiesis Laboratory, The University of Manchester, Manchester, UK.

Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan.

出版信息

Blood Cancer J. 2024 Jul 12;14(1):112. doi: 10.1038/s41408-024-01087-7.

DOI:10.1038/s41408-024-01087-7
PMID:38997261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11245466/
Abstract
摘要

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本文引用的文献

1
Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management.慢性粒单核细胞白血病：2024 年诊断、风险分层和治疗更新。
Am J Hematol. 2024 Jun;99(6):1142-1165. doi: 10.1002/ajh.27271. Epub 2024 Mar 7.
2
Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.单细胞多组学鉴定慢性炎症是 TP53 突变型白血病演变的驱动因素。
Nat Genet. 2023 Sep;55(9):1531-1541. doi: 10.1038/s41588-023-01480-1. Epub 2023 Sep 4.
3
Somatic TP53 single nucleotide variants, indels and copy number alterations in chronic myelomonocytic leukemia (CMML).
慢性粒单核细胞白血病（CMML）中的体细胞TP53单核苷酸变异、插入缺失及拷贝数改变
Leukemia. 2023 Aug;37(8):1753-1756. doi: 10.1038/s41375-023-01964-3. Epub 2023 Jul 8.
4
A three-gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia.一种三基因白血病干细胞特征评分在慢性粒单核细胞白血病中具有可靠的预后价值。
Br J Haematol. 2023 Apr;201(2):302-307. doi: 10.1111/bjh.18681. Epub 2023 Feb 6.
5
Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome.突变型 TP53 急性髓系白血病和高危骨髓增生异常综合征的分子特征。
Blood. 2022 Apr 14;139(15):2347-2354. doi: 10.1182/blood.2021014472.
6
TP53 mutations confer resistance to hypomethylating agents and BCL-2 inhibition in myeloid neoplasms.TP53突变使髓系肿瘤对低甲基化剂和BCL-2抑制产生耐药性。
Blood Adv. 2022 Jun 14;6(11):3201-3206. doi: 10.1182/bloodadvances.2021005859.
7
A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development.p53功能的一个不同方面：肿瘤发生过程中免疫与炎症的调节
Front Cell Dev Biol. 2021 Oct 18;9:762651. doi: 10.3389/fcell.2021.762651. eCollection 2021.
8
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.癌症基因组图谱中 TP53 基因与通路改变的综合分析。
Cell Rep. 2019 Jul 30;28(5):1370-1384.e5. doi: 10.1016/j.celrep.2019.07.001.
9
The multiple mechanisms that regulate p53 activity and cell fate.调控 p53 活性和细胞命运的多种机制。
Nat Rev Mol Cell Biol. 2019 Apr;20(4):199-210. doi: 10.1038/s41580-019-0110-x.
10
Transcriptomic rationale for synthetic lethality-targeting ERCC1 and CDKN1A in chronic myelomonocytic leukaemia.慢性粒单核细胞白血病中靶向 ERCC1 和 CDKN1A 的合成致死转录组学原理。
Br J Haematol. 2018 Aug;182(3):373-383. doi: 10.1111/bjh.15408. Epub 2018 May 24.