Kaattari S L, Irwin M J
Dev Comp Immunol. 1985 Summer;9(3):433-44. doi: 10.1016/0145-305x(85)90006-0.
An O-antigen extract of the fish pathogen Vibrio anguillarum was used to stimulate plaque-forming cells (PFC) in coho salmon. The kinetics of the response demonstrates peak PFC per organ on day 16 post immunization for the spleen and anterior kidney. Significant PFC were also seen in thymic tissue. PFC responses were shown to be immunoglobulin mediated and antigen specific. Inhibition profiles of responding PFC populations demonstrate that the cells of the anterior kidney are more restricted in their recognition of antigen than those of the spleen. These data lend functional support to the concept of the hematopoietic nature of the anterior kidney of teleosts.
鱼类病原体鳗弧菌的O抗原提取物被用于刺激银大麻哈鱼中的空斑形成细胞（PFC）。反应动力学表明，免疫后第16天脾脏和前肾的每个器官的PFC达到峰值。胸腺组织中也观察到显著的PFC。PFC反应显示是由免疫球蛋白介导且具有抗原特异性。反应性PFC群体的抑制谱表明，前肾细胞对抗原的识别比脾细胞更具限制性。这些数据为硬骨鱼前肾造血性质的概念提供了功能支持。
