钯催化的亚烷基吡唑啉酮、碳酸烯丙酯与活性亚甲基化合物之间的三组分脱羧偶联反应。

Pd-Catalyzed three-component decarboxylative coupling reactions between alkylidene pyrazolones, allyl carbonates and active methylene compounds.

作者信息

Zhang Heng, Cai Lu-Yu, Wang Kuo, Zhao Hong-Wu

机构信息

College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing 100124, P. R. China.

出版信息

Org Biomol Chem. 2022 Jun 29;20(25):5115-5124. doi: 10.1039/d2ob00791f.

DOI:10.1039/d2ob00791f

PMID:35703433

Abstract

Under the catalysis of Pd(dba)·CHCl/(±)-L5 in THF at room temperature, the three-component decarboxylative coupling reactions among alkylidene pyrazolones, allyl carbonates and active methylene compounds proceeded readily and furnished the desired products in acceptable chemical yields. The chemical architecture of the obtained products was unambiguously confirmed by single crystal X-ray analysis.

摘要

在室温下，于四氢呋喃中，在Pd(dba)·CHCl/(±)-L5的催化作用下，亚烷基吡唑啉酮、碳酸烯丙酯和活性亚甲基化合物之间的三组分脱羧偶联反应顺利进行，并以可接受的化学产率得到了所需产物。通过单晶X射线分析明确证实了所得产物的化学结构。